Factors that influence the cutaneous synthesis and dietary sources of vitamin D
Factors that influence the cutaneous synthesis and dietary sources of vitamin D
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DOI：
10.1016/j.abb.2006.12.017
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发表时间：
2007-04-15
影响因子：
3.9
通讯作者：
Holick, Michael F.
中科院分区：
文献类型：
--
作者：
Chen, Tai C.;Chimeh, Farhad;Holick, Michael F.
大多数人维生素D的主要来源是皮肤偶然暴露于太阳紫外线B（UVB; 290-315 nm）辐射和饮食摄入。维生素D的皮肤合成是皮肤色素沉着和太阳天顶角的函数，太阳天顶角取决于纬度，季节和一天中的时间。为了模拟皮肤暴露于阳光的自然环境，我们因此测量了不同皮肤类型的志愿者在重复紫外线照射后的血清25-羟基维生素D水平。由于人类皮肤中的黑色素竞争并吸收负责7-脱氢胆固醇光解为前维生素D-3的UVB光子，我们还研究了皮肤色素沉着对人体皮肤模型中前维生素D-3产生的影响，方法是将II型和V型皮肤样本暴露于6月太阳天顶角最尖锐的正午阳光下。维生素D在食物中很少见。在富含维生素D的食物中，油性鱼类被认为是最好的来源之一。因此，我们分析了几种常见食用的油性和非油性鱼类中的维生素D含量。数据显示，养殖鲑鱼的维生素D平均含量与阿拉斯加野生鲑鱼中的平均含量的25%相似，并且在养殖鲑鱼中发现了维生素D-2，但在野生鲑鱼中没有发现。这些结果为通过皮肤合成和饮食摄入获得足够的维生素D-3提供了有用的全球指南，以预防维生素D缺乏及其健康后果，随后的疾病，特别是老年人的骨折。(c)2007年爱思唯尔公司All rights reserved.
The major sources of vitamin D for most humans are casual exposure of the skin to solar ultraviolet B (UVB; 290-315 nm) radiation and from dietary intake. The cutaneous synthesis of vitamin D is a function of skin pigmentation and of the solar zenith angle which depends on latitude, season, and time of day. In order to mimic the natural environment of skin to sunlight exposure, we therefore measured serum 25-hydroxyvitamin D levels in volunteers with different skin types following repeated UV irradiation. Because melanin pigment in human skin competes for and absorbs the UVB photons responsible for the photolysis of 7-dehydrocholesterol to previtamin D-3, we also studied the effect of skin pigmentation on previtamin D-3 production in a human skin model by exposing type II and type V skin samples to noon sunlight in June when the solar zenith angle is most acute. Vitamin D is rare in food. Among the vitamin D-rich food, oily fish are considered to be one of the best sources. Therefore, we analyzed the vitamin D content in several commonly consumed oily and non-oily fish. The data showed that farmed salmon had a mean content of vitamin D that was similar to 25% of the mean content found in wild caught salmon from Alaska, and that vitamin D-2 was found in farmed salmon, but not in wild caught salmon. The results provide useful global guidelines for obtaining sufficient vitamin D-3 by cutaneous synthesis and from dietary intake to prevent vitamin D deficiency and its health consequences, ensuing illness, especially, bone fractures in the elderly. (c) 2007 Elsevier Inc. All rights reserved.