Double cancer - hepatocellular carcinoma and intrahepatic cholangiocarcinoma with a spindle-cell variant.
Double cancer - hepatocellular carcinoma and intrahepatic cholangiocarcinoma with a spindle-cell variant.
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DOI：
10.1007/s005340050144
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发表时间：
1999-01-01
期刊：
影响因子：
--
通讯作者：
Shimamoto, F
中科院分区：
文献类型：
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作者：
Itamoto, T;Asahara, T;Shimamoto, F
摘要肝内胆管细胞癌合并梭形细胞变异是非常罕见的。我们在这里报告一个外科病人谁有双重癌症-肝细胞癌（HCC）和ICC与梭形细胞变异。在这位70岁的男性患者中，约2年前曾因HCC行肝切除术，在肝右叶发现两个大的离散肿块。进行了肝右叶切除术。病理结果显示，一个肿瘤是典型的HCC，另一个是ICC伴肉瘤样病变。ICC肉瘤病变的免疫组化检查显示，一些梭形细胞角蛋白、上皮膜抗原和波形蛋白呈阳性，但S-100蛋白、结蛋白和肌动蛋白呈阴性。根据这些发现，我们得出结论，ICC的肉瘤样病变不是真正的肉瘤，而是胆管癌细胞的肉瘤样转化，即ICC的梭形细胞变体。
Intrahepatic cholangiocarcinoma (ICC) with a spindle-cell variant is very rare. We report here a surgical patient who had double cancer - hepatocellular carcinoma (HCC) and ICC with a spindle-cell variant. In this 70-year-old man, who had a history of hepatic resection for HCC about 2 years previously, two large discrete masses were identified in the right lobe of the liver. A right lobectomy of the liver was performed. Pathological findings revealed that one tumor was a typical HCC, and the other was ICC with sarcomatous lesions. Immunohistochemical examinations of the sarcomatous lesions in ICC demonstrated that some of the spindle cells were positive for keratin, epithelial membrane antigen, and vimentin, but negative for S-100 protein, desmin, and actin. From these findings, we concluded that the sarcomatous lesions of ICC were not a true sarcoma, but sarcomatous transformation of cholangiocarcinoma cells, that is, a spindle-cell variant of ICC.