The ocular hypertensive effects of topical 0.1% dexamethasone in beagles with inherited glaucoma
The ocular hypertensive effects of topical 0.1% dexamethasone in beagles with inherited glaucoma
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DOI：
10.1089/jop.1998.14.57
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发表时间：
1998-02-01
影响因子：
2.3
通讯作者：
Mackay, EO
中科院分区：
文献类型：
--
作者：
Gelatt, KN;Mackay, EO
局部0.1%地塞米松（50 μ l）滴注QID在昏迷的比格犬眼内压（IOP）增加约5毫米汞柱在第一个7至10天内，在四周的测试。IOP水平升高持续到药物滴注停止。药物眼和安慰剂眼IOP水平均显著高于给药前（对照）IOP。在小于7月龄的青光眼饲养比格犬与年龄较大的青光眼比格犬中，与局部地塞米松相关的IOP变化的比较未检测到任何显著差异。两个年龄组的IOP升高幅度约为4.8 mmHg。在停止局部地塞米松滴注后的一周内，药物和安慰剂眼的IOP均下降至给药前水平。比格犬的原发性开角型青光眼在单侧或双侧0.1%地塞米松QID滴注后表现出IOP显著和快速升高。
Topical 0.1% dexamethasone(50 mu l) instilled QID in glaucomatous Beagles increased intraocular pressure (IOP) by about 5 mm Hg within the first seven to ten days in a four week test. The elevated levels of IOP persisted until drug instillations ceased. Both drug eye and placebo eye IOP levels were increased significantly over the predrug (control) IOPs. Comparisons of the IOP changes associated with topical dexamethasone in beagles bred for glaucoma and less than seven months of age to older glaucomatous Beagles did not detect any significant differences. The magnitude of elevation in IOP in both age groups was about 4.8 mmHg. During the week after cessation of the topical dexamethasone instillations, IOPs of both the drug and placebo eyes declined toward predrug levels. Primary open angle glaucoma in the Beagle exhibits a significant and rapid elevation in IOP following unilateral or bilateral 0.1% dexamethasone instilled QID.