Myocardial and skeletal muscle glucose uptake during exercise in humans
Myocardial and skeletal muscle glucose uptake during exercise in humans
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DOI：
10.1113/jphysiol.2002.018135
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发表时间：
2002-07-15
影响因子：
5.5
通讯作者：
Knuuti, J
中科院分区：
文献类型：
--
作者：
Kemppainen, J;Fujimoto, T;Knuuti, J
本研究的目的是探讨运动对心肌葡萄糖摄取的影响以及葡萄糖摄取模式是否与骨骼肌相同。使用正电子发射断层扫描（PET）和2-[F-18]氟-2-脱氧-D-葡萄糖（[F-18]FDG）测量葡萄糖摄取。 12 名健康男性在休息期间进行了研究，而 14 名受试者在 35 分钟的自行车运动后进行了研究，相当于三天最大耗氧量 ((V)over dot(O2,max)) 的 30,55 和 75%。运动开始10分钟后注射[F-18]FDG，并继续运动25分钟。运动结束后立即开始心肌和骨骼肌 PET 扫描。与静息状态相比，运动强度为 30%（P = 0.056）和 55%（P < 0.05）时，心肌葡萄糖摄取量增加了一倍，而运动强度为 75% 时，与较低运动强度相比，心肌葡萄糖摄取量显着降低。最高强度水平与静息状态之间没有显着差异（P = 0.18）。在休息和低强度运动期间，心肌葡萄糖摄取与游离脂肪酸的循环水平呈负相关。然而，在较高的运动强度下，当血浆乳酸浓度显着增加时，这种关联消失了。与心肌反应相反，骨骼肌葡萄糖摄取量与运动强度平行上升，从休息到 30%，然后超过 dot(O2,max) 55% (V) (P < 0.001)，并且在强度为 75% 时倾向于进一步增加 (P = 0.065)。总之，这些结果表明，在轻度和中等强度运动期间，心肌葡萄糖摄取增加，但在高强度运动期间减少。这一发现表明，高强度运动期间所需的增加的心肌能量是由葡萄糖以外的底物提供的。
The purpose of this study was to investigate the effects of exercise on myocardial glucose uptake and Whether the pattern of glucose uptake is the same as in skeletal muscle. Glucose uptake was measured using positron emission tomography (PET) and 2-[F-18]fluoro-2-deoxy-D-glucose ([F-18]FDG). Twelve healthy men were studied during rest, while 14 subjects were studied after 35 min of bicycle exercise corresponding to 30,55 and 75% of maximal oxygen consumption ((V)over dot(O2,max)) on three separate days. [F-18]FDG was injected 10 min after the start of exercise and exercise continued for a further 25 min. Myocardial and skeletal muscle PET scanning was commenced directly after the completion of the exercise bout. As compared to the resting state, exercise doubled myocardial glucose uptake at the 30% (P = 0.056) and 55% intensity levels (P < 0.05), while at the 75% intensity level glucose uptake was reduced significantly compared to the lower exercise intensities. There was no significant difference between the highest intensity level and the resting state (P = 0.18). At rest and during low-intensity exercise, myocardial glucose uptake was inversely associated with circulating levels of free fatty acids. However, during higher exercise intensities when plasma lactate concentrations increased significantly, this association disappeared. In contrast to, myocardial responses, skeletal muscle glucose uptake rose in parallel with exercise intensity from rest to 30% and then 55% (V)over dot(O2,max) (P < 0.001) and tended to increase further at the intensity of 75% (P = 0.065). In conclusion, these results demonstrate that myocardial glucose uptake is increased during mild- and moderate-intensity exercise, but is decreased during high-intensity exercise. This finding suggests that the increased myocardial energy that is needed during high-intensity exercise is supplied by substrates other than glucose.