Testosterone and depression in men
Testosterone and depression in men
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DOI：
10.1097/med.0b013e3282fc27eb
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发表时间：
2008-06-01
影响因子：
3.2
通讯作者：
Seidman, Stuart N.
中科院分区：
文献类型：
--
作者：
Amiaz, Revital;Seidman, Stuart N.
综述的目的综述的目的是更新目前有关睾酮在抑郁性疾病中的作用的文献。我们已经考虑了内源性睾酮(即性腺功能减退和抑郁)和外源性睾酮(即潜在的抗抑郁剂)对抑郁的影响。最近的研究结果并不支持睾酮水平与情绪之间的一致关系。可能存在性腺功能减退导致抑郁的脆弱亚群；慢性抑郁症可能会导致某些男性性腺功能减退。来自多个随机对照临床试验的结果相互矛盾。大多数人不支持睾酮作为一种广泛有效的抗抑郁剂，但它可能在精心挑选的人群中有效，例如性腺功能低下的男性、抗抑郁药物抵抗的男性、早发性抑郁症患者和/或艾滋病毒感染的男性。摘要几乎没有人支持睾酮对情绪的普遍影响。
Purpose of review The purpose of the review is to update the current literature regarding the role, if any, that testosterone plays in depressive illness. We have considered the influences on depression of endogenous testosterone, that is, hypogonadism and depression; and exogenous testosterone, that is, as a potential antidepressant.Recent findings Studies do not support a consistent relationship between testosterone level and mood. There may be vulnerable subpopulations in whom hypogonadism contributes to depression; and chronic depressive illness may lead to hypogonadism in some men. Results from multiple randomized, controlled clinical trials are conflicting. Most do not support testosterone as a broadly effective antidepressant, but it may be effective in carefully selected populations, such as hypogonadal men, antidepressant-resistant men, men with early onset depression, and/or HIV-infected men.Summary There is little support for a pervasive influence of testosterone on mood.