HUMORAL AND CELL-MEDIATED-IMMUNITY TO THE PLASMODIUM-FALCIPARUM RING-INFECTED ERYTHROCYTE SURFACE-ANTIGEN IN AN ADULT-POPULATION EXPOSED TO HIGHLY ENDEMIC MALARIA
HUMORAL AND CELL-MEDIATED-IMMUNITY TO THE PLASMODIUM-FALCIPARUM RING-INFECTED ERYTHROCYTE SURFACE-ANTIGEN IN AN ADULT-POPULATION EXPOSED TO HIGHLY ENDEMIC MALARIA
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DOI：
10.1128/iai.63.2.596-600.1995
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发表时间：
1995-02-01
影响因子：
3.1
通讯作者：
ALPERS, M
中科院分区：
文献类型：
--
作者：
BECK, HP;FELGER, I;ALPERS, M
在巴布亚新几内亚疟疾高度流行地区进行了寄生虫学和免疫学调查，对214名成人进行了疟疾疫苗候选环状感染红细胞表面抗原(RESA)、针对RESA的总免疫球蛋白G(IgG)抗体以及特异性IgG1、IgG2和IgG3抗体的检测，结果表明，针对RESA的体液反应在所有IgG亚类中都是常见的。仅有IgG3反应与年龄相关。根据寄生虫流行率、寄生虫密度或卫生中心就诊率来衡量，总的抗RESA免疫球蛋白抗体与预防疟疾无关。相比之下，嗜细胞性抗体(IgG1和IgG3)与恶性疟原虫流行率降低和卫生中心就诊减少相关。总体而言，T细胞的增殖很低，而且非常罕见。体液免疫反应和细胞免疫反应之间没有相关性。在体液和细胞免疫反应良好的个体中，寄生虫密度、寄生虫流行率和去卫生中心就诊的人往往会减少。
A parasitological and immunological survey was carried out in an area in Papua New Guinea highly endemic for malaria, Two hundred fourteen adult individuals were selected for studies to assess their immune responses against the malaria vaccine candidate ring-infected erythrocyte surface antigen (RESA), Total immunoglobulin G (IgG) antibodies directed against RESA as well as specific IgG1, IgG2, and IgG3 antibodies were determined, Humoral responses directed against RESA were frequent in all IgG subclasses. Only IgG3 responses were found to be age dependent. Total anti-RESA IgG antibodies were not correlated with protection against malaria as measured by parasite prevalence, parasite density, or health center attendance. In contrast, cytophilic antibodies (IgG1 and IgG3) were associated with reduced Plasmodium falciparum prevalence and reduced health center attendance. T-cell proliferation in general was low and very infrequent. No correlation between humoral and cellular immune responses could be found. Parasite density, parasite prevalence, and health center visits tended to be reduced in individuals with good humoral and cell-mediated immune responses.