IN VITRO STUDY OF A NOVEL LOW-DENSITY LIPOPROTEIN ADSORBENT
IN VITRO STUDY OF A NOVEL LOW-DENSITY LIPOPROTEIN ADSORBENT
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DOI：
10.1081/bio-120002727
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发表时间：
2002-01
期刊：
影响因子：
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通讯作者：
Ning-Ning Cao-Ning;Yao-ting Yu;Man-Yan Wang;Changzhi Chen
中科院分区：
文献类型：
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作者：
Ning-Ning Cao-Ning;Yao-ting Yu;Man-Yan Wang;Changzhi Chen
高胆固醇血症已被确定为过早动脉粥样硬化发展的主要风险，其临床后遗症与冠状动脉疾病和心肌梗死相似。人们普遍认为，低密度脂蛋白（LDL）胆固醇水平高于130 mg/dl与冠心病的发病率非常高（1）。最近科学家发现，通过饮食，运动和药物大幅降低LDL可以阻止冠状动脉狭窄的进展，甚至诱导动脉粥样硬化病变的消退（2）。然而，在许多情况下，仅通过保守治疗不能充分降低LDL-胆固醇，例如家族性高胆固醇血症，以及通过血浆置换进一步体外清除LDL。
Hypercholesterolemia has been identified as a major risk in the development of premature atherosclerosis and in its clinical sequelae is similar to coronary artery disease and myocardial infarction. It is generally agreed that low-density lipoprotein (LDL) cholesterol levels above 130 mg/dl are associated with a very high incidence of coronary heart disease (1). Recently scientists found that drastic reductions of LDL by diet, exercise, and drugs can stop the progression of coronary stenoses or even induce regression of atherosclerotic lesions (2). However, a sufficient reduction of LDL-cholesterol can not be attained by conservative treatment alone in many instances, such as familiar hypercholesterolemia, and further extracorporeal LDL removal by plasmaphe-