Kinetics of non-isothermal cold-crystallization of carbamazepine in the glassy state studied by DSC
Kinetics of non-isothermal cold-crystallization of carbamazepine in the glassy state studied by DSC
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DOI：
10.1016/j.jnoncrysol.2021.121198
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发表时间：
2021-10-01
影响因子：
3.5
通讯作者：
Zielinski, Piotr M.
中科院分区：
文献类型：
--
作者：
Dolega, Agnieszka;Zielinski, Piotr M.
用差示扫描量热法研究了卡马西平(CBZ)在不同升温速率下的非等温冷结晶动力学。深入讨论了Johnson-Mehl-Avrami、Kisinger、Augis-Bennett、Ozawa、Mo和Matusita模型与形核和生长机制的相关性。Johnson-Mehl-Avrami和Kisinger模型的某些假设在描述急冷CBZ的冷结晶动力学时是不充分的。Augis-Bennett、Ozawa和Mo模型正确地描述了形核和生长机制，但它们不能区分表面结晶和整体结晶。松下模型是唯一一个能够正确描述这两种机制的模型，因此被认为是最通用的模型。急冷CBZ在较低和较高升温速率下表现出两种不同的结晶机制。在第一种情况下，表面结晶占主导地位，而在第二种情况下--体相结晶。活化能与升温速率、温度和晶化程度有关。
Kinetics of non-isothermal cold-crystallization of quench-cooled carbamazepine (CBZ) was investigated under different heating rates using Differential Scanning Calorimetry. Relevance of Johnson-Mehl-Avrami, Kissinger, Augis-Bennett, Ozawa, Mo and Matusita models to describe the mechanism of nucleation and growth was thoroughly discussed. Some assumptions of Johnson-Mehl-Avrami and Kissinger models were showed to be inadequate when describing kinetics of cold-crystallization of quench-cooled CBZ. Augis-Bennett, Ozawa and Mo models correctly outlined the nucleation and growth mechanism, however they were not able to distinguish between surface and bulk crystallization. Matusita model was the only one which properly described these two mechanisms and consequently was considered as the most versatile one. Quench-cooled CBZ displayed two different crystallization mechanisms for lower and higher heating rates. In the first case, surface crystallization was dominant, whereas in the second case - the bulk one. Activation energy was noticed to be heating rate, temperature and fractional extent of crystallization dependant.