Toward Consensus on Correct Interpretation of Protein Binding in Plasma and Other Biological Matrices for COVID-19 Therapeutic Development.
Toward Consensus on Correct Interpretation of Protein Binding in Plasma and Other Biological Matrices for COVID-19 Therapeutic Development.
复制标题
DOI：
10.1002/cpt.2099
复制
发表时间：
2021-07
影响因子：
6.7
通讯作者：
Owen A
中科院分区：
文献类型：
--
作者：
Boffito M;Back DJ;Flexner C;Sjö P;Blaschke TF;Horby PW;Cattaneo D;Acosta EP;Anderson P;Owen A
严重急性呼吸道综合征-冠状病毒2型（SARS-CoV-2）带来的全球公共卫生需求迫切，来自不同背景的科学家们聚集在一起，开展前所未有的国际努力，以迅速确定干预措施。迫切需要应用临床药理学原则，这已经被其他几个小组所认识。然而，需要额外具体考虑的一个领域涉及广泛影响药代动力学和药效学的血浆和组织蛋白结合。自由药物理论的原则已经被建立并应用于药物开发，但目前还没有被常规应用于SARS-CoV-2抗病毒药物。考虑蛋白结合对于候选物选择至关重要，但需要以药物特异性方式进行正确解释，以避免对其后果的解释不足或过度解释。这篇论文代表了寻求应用历史知识的国际研究人员的共识，这些知识支撑了数十年来针对其他病毒（如HIV和丙型肝炎病毒）的非常成功的抗病毒药物开发。
The urgent global public health need presented by severe acute respiratory syndrome‐coronavirus 2 (SARS‐CoV‐2) has brought scientists from diverse backgrounds together in an unprecedented international effort to rapidly identify interventions. There is a pressing need to apply clinical pharmacology principles and this has already been recognized by several other groups. However, one area that warrants additional specific consideration relates to plasma and tissue protein binding that broadly influences pharmacokinetics and pharmacodynamics. The principles of free drug theory have been forged and applied across drug development but are not currently being routinely applied for SARS‐CoV‐2 antiviral drugs. Consideration of protein binding is of critical importance to candidate selection but requires correct interpretation, in a drug‐specific manner, to avoid either underinterpretation or overinterpretation of its consequences. This paper represents a consensus from international researchers seeking to apply historical knowledge, which has underpinned highly successful antiviral drug development for other viruses, such as HIV and hepatitis C virus for decades.
登录
查看更多内容
影响因子：
4.4
作者：
Kimhofer, Torben;Lodge, Samantha;Nicholson, Jeremy K.
通讯作者：
Nicholson, Jeremy K.
影响因子：
12.7
作者：
Ko, Meehyun;Jeon, Sangeun;Kim, Seungtaek
通讯作者：
Kim, Seungtaek
影响因子：
4.9
作者：
Marzolini, Catia;Stader, Felix;Sendi, Parham
通讯作者：
Sendi, Parham
影响因子：
4.9
作者：
Hickman, D;Vasavanonda, S;Kempf, DJ
通讯作者：
Kempf, DJ
影响因子：
16.6
作者：
Sheahan, Timothy P.;Sims, Amy C.;Baric, Ralph S.
通讯作者：
Baric, Ralph S.