NEUROFIBRILLARY CHANGES CONFINED TO THE ENTORHINAL REGION AND AN ABUNDANCE OF CORTICAL AMYLOID IN CASES OF PRESENILE AND SENILE DEMENTIA
NEUROFIBRILLARY CHANGES CONFINED TO THE ENTORHINAL REGION AND AN ABUNDANCE OF CORTICAL AMYLOID IN CASES OF PRESENILE AND SENILE DEMENTIA
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DOI：
10.1007/bf00294607
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发表时间：
1990-01-01
影响因子：
12.7
通讯作者：
BRAAK, E
中科院分区：
文献类型：
--
作者：
BRAAK, H;BRAAK, E
例老年痴呆患者表现出丰富的皮质淀粉样蛋白沉积，但只有少数神经元的变化。神经炎斑块罕见或不存在。无论是Ammon的角还是同皮质都没有显示出足够多的缠结，以允许诊断完全发展的阿尔茨海默病。仅在Pre-α层中发生神经纤维缠结和神经纤维丝的密集积聚。(II)内嗅区这种皮质破坏的模式可能代表阿尔茨海默病的一种变体或这种疾病的初始阶段。
Cases of old-aged demented individuals exhibited abundant cortical amyloid deposits but only small numbers of neurofibrillary changes. Neuritic plaques were rare or absent. Neither Ammon''s horn nor isocortex revealed sufficiently large numbers of tangles to permit the diagnosis of fully developed Alzheimer''s disease. Dense accumulations of neurofibrillary tangles and neuropil threads occurred only in layer Pre-.alpha. (II) of the entorhinal region. This pattern of cortical destruction may represent a variant of Alzheimer''s disease or an initial stage of this disorder.