CXCR4+ granulocytes reflect fungal cystic fibrosis lung disease
CXCR4+ granulocytes reflect fungal cystic fibrosis lung disease
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DOI：
10.1183/09031936.00173514
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发表时间：
2015-08-01
影响因子：
24.3
通讯作者：
Hartl, Dominik
中科院分区：
文献类型：
--
作者：
Carevic, Melanie;Singh, Anurag;Hartl, Dominik
囊性纤维化气道经常被真菌定植。然而，这些真菌与免疫细胞的相互作用以及在囊性纤维化肺疾病中的临床相关性尚不完全清楚。非囊性纤维化疾病对照和健康对照受试者交叉-并将这些结果与肺功能参数相关联。表达HIV辅助受体CXCR 4的不同粒细胞亚群的积聚。在囊性纤维化患者中，气道CXCR 4（+）粒细胞的数量与肺部疾病的严重程度相关。CXCR 4（+）气道粒细胞可能作为真菌性囊性纤维化肺病的潜在生物标志物和治疗靶点。
Cystic fibrosis airways are frequently colonised with fungi. However, the interaction of these fungi with immune cells and the clinical relevance in cystic fibrosis lung disease are incompletely understood.We characterised granulocytes in airway fluids and peripheral blood from cystic fibrosis patients with and without fungal colonisation, non-cystic fibrosis disease controls and healthy control subjects cross-sectionally and longitudinally and correlated these findings with lung function parameters.Cystic fibrosis patients with chronic fungal colonisation by Aspergillus fumigatus were characterised by an accumulation of a distinct granulocyte subset, expressing the HIV coreceptor CXCR4. Percentages of airway CXCR4(+) granulocytes correlated with lung disease severity in patients with cystic fibrosis.These studies demonstrate that chronic fungal colonisation with A. fumigatus in cystic fibrosis patients is associated with CXCR4(+) airway granulocytes, which may serve as a potential biomarker and therapeutic target in fungal cystic fibrosis lung disease.