Steroid binding to cardiac Type I receptors: in vivo studies
Steroid binding to cardiac Type I receptors: in vivo studies
复制标题
类固醇与心脏 I 型受体的结合：体内研究
DOI：
10.1097/00004872-198812040-00038
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发表时间：
1988
影响因子：
4.9
通讯作者：
J. Funder
中科院分区：
文献类型：
--
作者：
P. Pearce;J. Funder
In vitro, Type I (mineralocorticoid) receptors show equivalently high affinity for aldosterone, corticosterone and cortisol in cytosol preparations from a wide range of tissues. This steroid non-selectivity is also found for hippocampal Type I receptors in vivo; in contrast, Type I receptors in physiological mineralocorticoid target tissues are highly aldosterone-specific in vivo. In the present study we show that Type I receptors in the heart are non-selective in vivo, like those in hippocampus, and therefore presumably act as high-affinity glucocorticoid receptors rather than mineralocorticoid receptors.
