TaqIB polymorphism in the CETP gene modulates the impact of HC/LF diet on the HDL profile in healthy Chinese young adults
TaqIB polymorphism in the CETP gene modulates the impact of HC/LF diet on the HDL profile in healthy Chinese young adults
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DOI：
10.1016/j.jnutbio.2009.09.009
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发表时间：
2010-11-01
影响因子：
5.6
通讯作者：
Duan, Wei
中科院分区：
文献类型：
--
作者：
Du, Juan;Fang, Ding Zhi;Duan, Wei
本研究旨在探讨胆固醇酯转运蛋白（CETP）和低密度脂蛋白受体（LDLR）基因变异与高糖低脂（HC/LF）饮食对中国汉族健康青年人群血脂的影响。五十六例健康受试者（22.89 ± 1.80岁）给予31%脂肪和54%碳水化合物的洗脱饮食7天，然后给予15%脂肪和70%碳水化合物的HC/LF饮食6天，没有总能量限制。分析了基线、洗脱后和HC/LF饮食后的血脂谱，以及CETP和LDLR多态性。饮食干预后，CETP TaqIB多态性B2等位基因携带者的高密度脂蛋白胆固醇（HDL-C）和载脂蛋白A-I水平显著高于对照组。值得注意的是，CETP TaqIB B1 B1雄性动物在HC/LF饮食后HDL-C和apo A-I显著升高。关于LDLR Pvu II多态性，在HC/LF饮食后，P1 P1受试者和P2携带者的总胆固醇（TC）和低密度脂蛋白胆固醇（LDL-C）水平均降低，基因型之间无统计学显著差异。本研究结果表明，中国汉族健康青年HC/LF饮食后HDL-C水平升高与CETP TaqI B2等位基因相关，而B1 B1基因型男性更易受HC/LF饮食影响。HC/LF饮食后TC和LDL-C水平的降低与LDLR Pvu II多态性无关。(C)2010年爱思唯尔公司All rights reserved.
The aim of this study was to investigate the interactions of genetic variants in the genes of cholesterol ester transfer protein (CETP) and low-density lipoprotein receptor (LDLR) with high carbohydrate and low fat (HC/LF) diet on lipid profiles in a young and healthy Chinese Han population. Fifty-six healthy subjects (22.89 +/- 1.80 years) were given washout diets of 31% fat and 54% carbohydrate for 7 days, followed by HC/LF diets of 15% fat and 70% carbohydrate for 6 days, with no total energy restriction. Serum lipid profiles at baseline, after washout and following HC/LF diets, as well as CETP and LDLR polymorphisms were analyzed. Carriers of B2 allele of CETP TaqIB polymorphism had significantly higher levels of high density lipoprotein cholesterol (HDL-C) and apo A-I in the whole study population after the diet intervention. Notably, males with CETP TaqIB B1B1 experienced significantly increased HDL-C and apo A-I after HC/LF diet. Regarding the LDLR Pvu II polymorphism, both P1P1 subjects and P2 carriers experienced decreased total cholesterol (TC) and low-density lipoprotein cholesterol (LDL-C) levels after HC/LF diet with no statistically significant differences between the genotypes. Our results demonstrate that the elevated HDL-C levels after HC/LF diet in healthy Chinese Han youth are associated with CETP TaqI B2 allele while males with B1B1 genotype are more susceptible to the influence of HC/LF diet on their HDL-C levels. The decreased TC and LDL-C levels after HC/LF diet are not associated with LDLR Pvu II polymorphism. (C) 2010 Elsevier Inc. All rights reserved.