Collagen composition and content-dependent contrast in porcine annulus fibrosus achieved by using double quantum and magnetization transfer filtered UTE MRI.
Collagen composition and content-dependent contrast in porcine annulus fibrosus achieved by using double quantum and magnetization transfer filtered UTE MRI.
复制标题
通过使用双量子和磁化转移过滤 UTE MRI 实现猪纤维环中的胶原成分和含量依赖性对比度。
DOI：
10.1002/mrm.24662
复制
发表时间：
2014
影响因子：
3.3
通讯作者：
Navon,Gil
中科院分区：
文献类型：
--
作者：
Eliav,Uzi;Komlosh,MichalE;Basser,PeterJ;Navon,Gil
目的测试双量子和磁化转移滤波超短回波时间（DQF - MT - UTE） MRI相结合的潜力，以获得有关结缔组织大分子组成和特征的信息。方法采用DQF - MT - UTE脉冲序列，在14.1 T AVANCE III型Bruker光谱仪上配置Bruker micro2.5 -成像梯度系统，获取猪纤维环图像。结果双量子相干滤波（DQF）产生时间与大分子激发时间相适应的猪椎间盘纤维环的DQF - MT - UTE MRI显示，来自椎间盘外层的信号强于来自靠近髓核的内层的信号。同样，光谱学研究也显示了从胶原蛋白到水的磁化转移（MT）效率的相同趋势。结论dqf‐MT过滤纤维环的UTE MRI提供了新的对比参数，该参数依赖于胶原浓度及其质子对水的MT率和效率。纤维环中I型和II型胶原蛋白的后一参数似乎不同。中华医学杂志，2014,31(1):388 - 393。©2013 Wiley期刊公司
PurposeTo test the potential of combining double quantum and magnetization transfer filtered ultra‐short echo time (DQF‐MT‐UTE) MRI to obtain information about the macromolecular composition and characteristics of connective tissues.MethodsA DQF‐MT‐UTE pulse sequence was implemented on a 14.1 T AVANCE III Bruker spectrometer equipped with a Bruker micro2.5‐imaging gradient system to obtain images of porcine annulus fibrosus.ResultsThe DQF‐MT‐UTE MRI of the annulus fibrosus of porcine intervertebral disc, where the creation time of the double quantum coherence filtering (DQF) was on a time scale appropriate for excitation of macromolecules, showed stronger signal from the outer layers of the disc than from the inner layers closer to the nucleus pulposus. Similarly, spectroscopic studies showed the same trend in the efficiency of the magnetization transfer (MT) from collagen to water.ConclusionDQF‐MT filtered UTE MRI of the annulus fibrosus provides new contrast parameters that depend on the concentration of the collagen and on the rate and efficiency of MT of its protons to water. The latter parameters appear to be different for collagen types I and II in the annulus fibrosus.Magn Reson Med 71:388–393, 2014. © 2013 Wiley Periodicals, Inc.