B cell infiltration is highly associated with prognosis and an immune-infiltrated tumor microenvironment in neuroblastoma.
B cell infiltration is highly associated with prognosis and an immune-infiltrated tumor microenvironment in neuroblastoma.
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DOI：
10.20517/2394-4722.2021.72
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发表时间：
2021
期刊：
影响因子：
--
通讯作者：
Cheng C
中科院分区：
文献类型：
--
作者：
Schaafsma E;Jiang C;Cheng C
神经母细胞瘤是儿童最常见的颅外实体瘤。免疫治疗方法的最新进展，包括神经母细胞瘤，已经显示了免疫系统在建立有效的抗肿瘤反应中的重要作用。在这项研究中，我们的目的是利用大量的基因表达数据集提供一个全面的调查免疫细胞浸润神经母细胞瘤。我们使用已建立的免疫推断方法推断免疫细胞浸润，并评估免疫细胞丰度与患者预后以及神经母细胞瘤中常见染色体异常之间的关联。此外，我们评估了不同免疫细胞类型之间的共浸润模式。幼稚B细胞、NK细胞和CD8+ T细胞的浸润与患者预后改善相关。幼稚B细胞是预后最一致的指标，并与活跃的免疫肿瘤微环境相关。高B细胞浸润的患者表现出其他免疫细胞类型的高共浸润和免疫相关通路的富集。即使在调整临床变量后，高B细胞浸润的存在也与无复发和总生存期相关。在这项研究中，我们提供了一个全面的评估免疫细胞浸润的神经母细胞瘤基因表达数据。我们提出B细胞在神经母细胞瘤肿瘤微环境中的重要作用，并建议B细胞可用作预后生物标志物，以预测无复发和总生存率，而不依赖于目前使用的预后变量。
Neuroblastoma is the most common extracranial solid tumor in children. Recent advances in immunotherapy Approaches, including in neuroblastoma, have shown the important role of the immune system in mounting an effective anti-tumor response. In this study, we aimed to provide a comprehensive investigation of immune cell infiltration in neuroblastoma utilizing a large number of gene expression datasets. We inferred immune cell infiltration using an established immune inference method and evaluated the association between immune cell abundance and patient prognosis as well as common chromosomal abnormalities found in neuroblastoma. In addition, we evaluated co-infiltration patterns among distinct immune cell types. The infiltration of naïve B cells, NK cells, and CD8+ T cells was associated with improved patient prognosis. Naïve B cells were the most consistent indicator of prognosis and associated with an active immune tumor microenvironment. Patients with high B cell infiltration showed high co-infiltration of other immune cell types and the enrichment of immune-related pathways. The presence of high B cell infiltration was associated with both recurrence-free and overall survival, even after adjusting for clinical variables. In this study, we have provided a comprehensive evaluation of immune cell infiltration in neuroblastoma using gene expression data. We propose an important role for B cells in the neuroblastoma tumor microenvironment and suggest that B cells can be used as a prognostic biomarker to predict recurrence-free and overall survival independently of currently utilized prognostic variables.
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影响因子：
64.8
作者：
Helmink BA;Reddy SM;Gao J;Zhang S;Basar R;Thakur R;Yizhak K;Sade-Feldman M;Blando J;Han G;Gopalakrishnan V;Xi Y;Zhao H;Amaria RN;Tawbi HA;Cogdill AP;Liu W;LeBleu VS;Kugeratski FG;Patel S;Davies MA;Hwu P;Lee JE;Gershenwald JE;Lucci A;Arora R;Woodman S;Keung EZ;Gaudreau PO;Reuben A;Spencer CN;Burton EM;Haydu LE;Lazar AJ;Zapassodi R;Hudgens CW;Ledesma DA;Ong S;Bailey M;Warren S;Rao D;Krijgsman O;Rozeman EA;Peeper D;Blank CU;Schumacher TN;Butterfield LH;Zelazowska MA;McBride KM;Kalluri R;Allison J;Petitprez F;Fridman WH;Sautès-Fridman C;Hacohen N;Rezvani K;Sharma P;Tetzlaff MT;Wang L;Wargo JA
通讯作者：
Wargo JA
DOI：
10.1038/nrc3239
发表时间：
2012-03-22
期刊：
Nature reviews. Cancer
影响因子：
--
作者：
Pardoll DM
通讯作者：
Pardoll DM
DOI：
10.1126/science.aat6768
发表时间：
2018-12-07
期刊：
Science (New York, N.Y.)
影响因子：
--
作者：
Ackermann S;Cartolano M;Hero B;Welte A;Kahlert Y;Roderwieser A;Bartenhagen C;Walter E;Gecht J;Kerschke L;Volland R;Menon R;Heuckmann JM;Gartlgruber M;Hartlieb S;Henrich KO;Okonechnikov K;Altmüller J;Nürnberg P;Lefever S;de Wilde B;Sand F;Ikram F;Rosswog C;Fischer J;Theissen J;Hertwig F;Singhi AD;Simon T;Vogel W;Perner S;Krug B;Schmidt M;Rahmann S;Achter V;Lang U;Vokuhl C;Ortmann M;Büttner R;Eggert A;Speleman F;O'Sullivan RJ;Thomas RK;Berthold F;Vandesompele J;Schramm A;Westermann F;Schulte JH;Peifer M;Fischer M
通讯作者：
Fischer M
影响因子：
45.3
作者：
Coughlin, Christina M.;Fleming, Mark D.;Vonderheide, Robert H.
通讯作者：
Vonderheide, Robert H.
影响因子：
64.8
作者：
Cabrita, Rita;Lauss, Martin;Jonsson, Goran
通讯作者：
Jonsson, Goran