Impaired magnocellular/dorsal stream activation predicts impaired reading ability in schizophrenia
Impaired magnocellular/dorsal stream activation predicts impaired reading ability in schizophrenia
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DOI：
10.1016/j.nicl.2012.09.006
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发表时间：
2013-01-01
影响因子：
4.2
通讯作者：
Javitt, Daniel C.
中科院分区：
文献类型：
--
作者：
Martinez, Antigona;Revheim, Nadine;Javitt, Daniel C.
在健康人群中，通道阅读依赖于大细胞/背侧视觉通路所起的关键组织作用。在最近的一项研究中，我们发现精神分裂症患者的正字法阅读缺陷与对低空间频率刺激的对比敏感性缺陷之间存在显著相关性，这表明存在潜在的巨细胞加工异常。采用基于行为和功能磁共振成像（fMRI）的测量方法，对21例精神分裂症患者和17名健康对照者进行了大细胞功能障碍与传体阅读障碍之间的相互关系研究。在阅读段落和单字时，fMRI的激活模式与皮层区域的关系进行了评估，这些区域对低频和高空间频率皮层区域的敏感度不同，使用相位编码的fMRI范式进行了识别。平均而言，精神分裂症患者的阅读水平为6年级，尽管他们已经完成了12年以上的教育，并且在发病前的智商估计正常。精神分裂症患者对低空间频率的对比敏感度也明显受损，对低空间频率刺激的神经活动异常，这与大细胞加工功能障碍一致。此外，这些巨细胞缺陷预示着在文章阅读的标准化心理教育测试中表现不佳。这些发现表明阅读是精神分裂症认知功能障碍的重要指标，并突出了大细胞功能障碍对精神分裂症整体认知障碍的贡献。(C) 2012年作者。Elsevier Inc.出版。在CC BY-NC-SA许可下开放获取。
In healthy humans, passage reading depends upon a critical organizing role played by the magnocellular/dorsal visual pathway. In a recent study, we found a significant correlation between orthographic reading deficits in schizophrenia and deficits in contrast sensitivity to low spatial frequency stimuli, suggesting an underlying magnocellular processing abnormality. The interrelationship between magnocellular dysfunction and passage reading impairments in schizophrenia was investigated in 21 patients with schizophrenia and 17 healthy control volunteers using behavioral and functionalMRI (fMRI) based measures. fMRI activation patterns during passage- and single-word reading were evaluated in relation to cortical areas with differential sensitivity to low versus high spatial frequency cortical regions indentified using a phase-encoded fMRI paradigm. On average, patients with schizophrenia read at the 6th grade level, despite completion of more than 12 years of education and estimated normal pre-morbid IQ. Schizophrenia patients also showed significantly impaired contrast sensitivity to low spatial frequencies and abnormal neural activity in response to stimulation with low spatial frequencies, consistent with dysfunction of magnocellular processing. Further, these magnocellular deficits were predictive of poor performance on a standardized psychoeducational test of passage reading. These findings suggest that reading is an important index of cognitive dysfunction in schizophrenia and highlight the contribution of magnocellular dysfunction to overall cognitive impairments in schizophrenia. (C) 2012 The Authors. Published by Elsevier Inc. Open access under CC BY-NC-SA license.