El Escorial revisited: Revised criteria for the diagnosis of amyotrophic lateral sclerosis
El Escorial revisited: Revised criteria for the diagnosis of amyotrophic lateral sclerosis
复制标题
DOI：
10.1080/146608200300079536
复制
发表时间：
2000-12-01
期刊：
影响因子：
--
通讯作者：
Munsat, TL
中科院分区：
文献类型：
--
作者：
Brooks, BR;Miller, RG;Munsat, TL
肌萎缩侧索硬化症 (ALS) 是一种进行性神经退行性疾病，主要累及大脑皮层、脑干和脊髓的运动神经元。 ALS 病程早期临床表现的变异性以及缺乏任何生物诊断标记物使得绝对诊断变得困难，并损害了临床实践、治疗试验和其他研究目的中诊断的确定性。El Escorial 诊断 ALS 的标准1已被广泛接受，但人们认为应该对其进行修订，以提高其敏感性。下面描述的标准代表了世界神经学联合会运动神经元疾病研究委员会于 1998 年 4 月 2-4 日在弗吉尼亚州沃伦顿艾尔利会议中心召开的为期三天的研讨会的结果。
Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disorder involving primarily motor neurons in the cerebral cortex, brainstem and spinal cord. The variability in clinical findings early in the course of ALS and the lack of any biological diagnostic marker make absolute diagnosis difficult and compromise the certainty of diagnosis in clinical practice, therapeutic trials and other research purposes.The El Escorial criteria1 for the diagnosis of ALS have been widely accepted, but it was felt that they should be revised in order to increase their sensititvity. The criteria described below represent the result of a three-day workshop, convened at Airlie Conference Center, Warrenton, Virginia on 2–4 April, 1998 by the World Federation of Neurology Research Committee on Motor Neuron Diseases.