Functional Connectivity of the Macaque Brain across Stimulus and Arousal States
Functional Connectivity of the Macaque Brain across Stimulus and Arousal States
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DOI：
10.1523/jneurosci.0220-09.2009
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发表时间：
2009-05-06
影响因子：
5.3
通讯作者：
Freiwald, Winrich A.
中科院分区：
文献类型：
--
作者：
Moeller, Sebastian;Nallasamy, Nambi;Freiwald, Winrich A.
皮质网络产生时间相关的大脑活动。为了阐明这种相关活动的功能意义，我们询问其结构是否以及如何依赖于刺激和唤醒状态。通过对猕猴功能磁共振成像数据的独立成分分析，我们发现了大量的大脑网络在不同的视觉刺激环境中具有惊人的可重复性。在大脑警觉和麻醉状态下可重复的网络较少。网络复杂性范围从双边单节点网络到包含分布在 3 厘米皮层上的多个离散节点的网络；我们的调查中发现的一个网络包括双侧颞顶叶枕交界处、背侧前运动皮层、岛叶和后扣带皮层的部分区域。我们的结果揭示了警觉的猴子和麻醉的猴子的整个大脑中丰富的空间结构相关网络，并表明麻醉显着改变了这些网络的空间结构。
Cortical networks generate temporally correlated brain activity. To clarify the functional significance of this correlated activity, we asked whether and how its structure depends on stimulus and arousal state. Using independent components analysis of macaque functional magnetic resonance imaging data, we identified a large number of brain networks that were strikingly reproducible across different visual stimulus contexts. Fewer networks were reproducible across alert and anesthetized brain states. Network complexity ranged from bilateral single-node networks to networks comprising multiple discrete nodes distributed over 3 cm of cortex; one network identified in our survey included parts of the temporal parietal occipital junction, dorsal premotor cortex, insula, and posterior cingulate cortex bilaterally. Our results reveal the wealth of spatially structured correlated networks throughout the brain in both alert and anesthetized monkeys, and show that anesthesia significantly alters the spatial structure of these networks.