Receptor tyrosine kinase ErbB4 modulates neuroblast migration and placement in the adult forebrain
Receptor tyrosine kinase ErbB4 modulates neuroblast migration and placement in the adult forebrain
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DOI：
10.1038/nn1345
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发表时间：
2004-12-01
影响因子：
25
通讯作者：
Lai, C
中科院分区：
文献类型：
--
作者：
Anton, ES;Ghashghaei, HT;Lai, C
神经前体细胞的增殖、分化和迁移在成人脑的吻端迁移流中持续活跃。在这里，我们发现受体酪氨酸激酶ErbB4通过存在于脑室下区和吻部迁移流中的神经母细胞来显著表达。已被鉴定为ErbB4配体的神经调节蛋白(NRG1-NRG3)在溪流或邻近区域中被检测到。在nestin或hGFAP启动子的控制下，ErbB4基因缺陷表达的小鼠改变了神经母细胞链的组织和迁移，以及嗅觉间神经元的位置和分化缺陷。这些发现表明，ErbB4的激活有助于调节形成吻端迁移流的神经链的组织，并影响嗅觉神经元间前体的分化。
Neural progenitor proliferation, differentiation and migration are continually active in the rostral migratory stream of the adult brain. Here, we show that the receptor tyrosine kinase ErbB4 is expressed prominently by the neuroblasts present in the subventricular zone and the rostral migratory stream. The neuregulins (NRG1-NRG3), which have been identified as ErbB4 ligands, are detected either in the stream or in adjacent regions. Mice deficient in ErbB4 expressed under the control of either the nestin or the hGFAP promoter have altered neuroblast chain organization and migration and deficits in the placement and differentiation of olfactory interneurons. These findings suggest that ErbB4 activation helps to regulate the organization of neural chains that form the rostral migratory stream and influences the differentiation of olfactory interneuronal precursors.