Premature atrial contractions: A predictor of atrial fibrillation and a relevant marker of atrial cardiomyopathy.

Premature atrial contractions: A predictor of atrial fibrillation and a relevant marker of atrial cardiomyopathy.
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DOI:
10.3389/fphys.2022.971691
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发表时间:
2022
影响因子:
4
通讯作者:
--
中科院分区:
医学2区
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房性期前收缩(PAC)的负担增加一直被认为是一种良性现象。然而,强有力的证据表明,他们参与发生心房颤动(AF),缺血性中风,和死亡率过高,这表明需要管理。要解决的中心问题是异位房性心律增加是否只是AF的预测因子,还是心房心肌病的标志物,从而是缺血性卒中的标志物。在回顾了PAC的病理生理学及其对患者预后的影响后,本小型综述建议:1)详细说明PAC和AF之间的生理和临床因素,2)提出支持室上性异位活动作为心肌病标志物的证据,3)概述该概念的当前局限性和潜在的未来临床意义。
An increased burden of premature atrial contractions (PACs) has long been considered a benign phenomenon. However, strong evidence of their involvement in the occurrence of atrial fibrillation (AF), ischemic stroke, and excess mortality suggests the need for management. The central question to be resolved is whether increased ectopic atrial rhythm is only a predictor of AF or whether it is a marker of atrial cardiomyopathy and therefore of ischemic stroke. After reviewing the pathophysiology of PACs and its impact on patient prognosis, this mini-review proposes to 1) detail the physiological and clinical elements linking PACs and AF, 2) present the evidence in favor of supraventricular ectopic activity as a marker of cardiomyopathy, and 3) outline the current limitations of this concept and the potential future clinical implications.
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