Telescoping of caregiver report on the Autism Diagnostic Interview - Revised
Telescoping of caregiver report on the Autism Diagnostic Interview - Revised
复制标题
DOI：
10.1111/j.1469-7610.2011.02398.x
复制
发表时间：
2011-07-01
影响因子：
7.6
通讯作者：
Lord, Catherine
中科院分区：
文献类型：
--
作者：
Hus, Vanessa;Taylor, Amanda;Lord, Catherine
背景：发育迟缓是诊断自闭症谱系障碍（ASD）的一个基本特征。语言习得年龄通常通过照顾者回顾性报告获得，目前用于区分ASD内的不同类别。研究表明，照顾者经常报告儿童达到发育里程碑的时间比实际时间更早或更晚。本研究考察了这种被称为“时间压缩”的现象对自闭症儿童照顾者回顾性报告的影响程度。
方法：参与者是127名因可能患有自闭症或非谱系发育迟缓而被转诊的儿童的照顾者。在儿童2岁、3岁、5岁和9岁时对照顾者进行访谈。使用线性模型随时间比较照顾者报告的首次关注年龄、语言和非诊断性发育里程碑以及访谈者估计的发病年龄。
结果：语言里程碑的显著时间压缩导致随着年龄增长，更多儿童符合语言迟缓标准，尽管最初报告他们的语言没有迟缓。几乎没有证据表明照顾者报告的首次关注年龄、日间膀胱控制和独立行走的时间存在一致的压缩。随着时间推移，访谈者判断的症状发作年龄增加，但仍在3岁之前。
结论：照顾者报告的语言习得年龄的时间压缩对临床诊断和利用这些里程碑来提高样本同质性的遗传学研究都有影响。研究结果支持在自闭症诊断中取消特定年龄标准的提议。在处理任何使用回顾性回忆事件进行诊断的临床人群时，都应考虑时间压缩这一因素。
Background: Delays in development are a fundamental feature in diagnosing autism spectrum disorders (ASD). Age of language acquisition, usually obtained through retrospective caregiver report, is currently used to distinguish between categories within ASD. Research has shown that caregivers often report children as having acquired developmental milestones earlier or later than they were actually achieved. The current study examines the extent to which this phenomenon, referred to as 'telescoping,' impacts retrospective reports provided by caregivers of children with ASD. Methods: Participants were 127 caregivers of children referred for possible ASD or non-spectrum developmental delay. Caregivers were interviewed when children were 2, 3, 5, and 9 years of age. Caregiver-reported ages of first concern, language and non-diagnostic developmental milestones and interviewer-estimated age of onset were compared over time using linear models. Results: Significant telescoping of language milestones resulted in more children meeting language delay criteria as they grew older, in spite of original reports that their language was not delayed. There was little evidence of consistent telescoping of caregiver-reported ages of first concern, daytime bladder control, and independent walking. With time, the interviewers' judged ages of symptom onset increased, but remained prior to age three. Conclusions: Telescoping of caregiver-reported ages of language acquisition has implications for both clinical diagnosis and genetic studies using these milestones to increase homogeneity of samples. Results support proposals to remove specific age-based criteria in the diagnosis of ASD. Telescoping should be considered when working with any clinical population in which retrospectively recalled events are used in diagnosis.