Visuospatial performance in patients with statistically-defined mild cognitive impairment.
Visuospatial performance in patients with statistically-defined mild cognitive impairment.
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统计上定义的轻度认知障碍患者的视觉空间表现。
DOI：
10.1080/13803395.2020.1714550
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发表时间：
2020
影响因子：
2.2
通讯作者：
Libon,DavidJ
中科院分区：
文献类型：
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作者：
Wasserman,Victor;Emrani,Sheina;Matusz,EmilyF;Peven,Jamie;Cleary,Seana;Price,CatherineC;Ginsberg,TerrieBeth;Swenson,Rodney;Heilman,KennethM;Lamar,Melissa;Libon,DavidJ
简介：倾斜效应表示感知水平或垂直而不是对角或倾斜刺激的上级性能。本研究旨在探讨轻度认知功能障碍（MCI）患者对斜向测试刺激的反应。（非MCI，n = 39）;轻微认知损害（SCI，n = 15）;遗忘型MCI（aMCI，n = 28）;和组合的混合/执行障碍MCI（混合/dys MCI，n = 30）。使用判断线方向测试（JOLO）评估对倾斜与非倾斜测试刺激的反应能力。还获得了全面的神经心理学评估。分析了JOLO斜向和非斜向测试刺激的组间差异。分层线性回归模型构建，以确定准确性之间的关系，斜和非斜测试项目和neurocognitive domains.Results：混合/dys MCI组表现出较低的准确性斜测试项目相比，非MCI患者。准确的斜测试项目的反应与更好的性能测试测量执行控制，处理速度，命名/词汇检索，和口头概念的形成。无组间差异被视为非斜项目，这些项目与cognition.Conclusions：斜测试项目显着损害区分患者与多域/执行障碍MCI从非MCI患者。准确的斜测试项目的反应与一系列复杂的神经心理测试表明，多维神经心理技能的基础上成功的斜线识别所需的视觉空间推理能力。使用额外的神经心理学测试范例，以及MRI定义的感兴趣的神经解剖区域，将对倾斜与非倾斜测试刺激的反应关联起来的研究可能会提供有关MCI亚型基础的脑行为关系的额外信息。
Introduction:The Oblique Effect denotes superior performance for perceiving horizontal or vertical rather than diagonal or oblique stimuli. The current research investigated responding to oblique test stimuli in patients with mild cognitive impairment (MCI).Method: Four statistically-determined groups (n = 112) were studied; patients with little to no cognitive impairment (non-MCI, n = 39); subtle cognitive impairment (SCI, n = 15); amnestic MCI (aMCI, n = 28); and a combined mixed/dysexecutive MCI (mixed/dys MCI, n = 30). The ability to respond to oblique versus non-oblique test stimuli was assessed using the Judgment of Line Orientation Test (JOLO). Comprehensive neuropsychological assessment was also obtained. Between-group differences for JOLO oblique and non-oblique test stimuli were analyzed. Hierarchical linear regression models were constructed to identify relations between accuracy for oblique and non-oblique test items and neurocognitive domains.Results: The mixed/dys MCI group demonstrated lower accuracy for oblique test items compared to non-MCI patients. Accurate responding to oblique test items was associated with better performance on tests measuring executive control, processing speed, naming/lexical retrieval, and verbal concept formation. No between-group differences were seen for non-oblique items and these items were not associated with cognition.Conclusions:Significant impairment on oblique test items distinguished patients with multi-domain/dysexecutive MCI from non-MCI patients. Accurate responding to oblique test items was associated with a complex array of neuropsychological tests suggesting that multidimensional neuropsychological skills underlie the visuospatial reasoning abilities necessary for successful oblique line identification. Research associating responding to oblique versus non-oblique test stimuli using additional neuropsychological test paradigms, and MRI-defined neuroanatomical regions of interest may provide additional information about the brain-behavior relations that underlie MCI subtypes.