Elevated serum estradiol levels in artificial autologous frozen embryo transfer cycles negatively impact ongoing pregnancy and live birth rates
Elevated serum estradiol levels in artificial autologous frozen embryo transfer cycles negatively impact ongoing pregnancy and live birth rates
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DOI：
10.1007/s10815-017-1016-1
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发表时间：
2017-12-01
影响因子：
3.1
通讯作者：
Buyuk, Erkan
中科院分区：
文献类型：
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作者：
Fritz, Rani;Jindal, Sangita;Buyuk, Erkan
本研究的目的是评估人工自体冷冻胚胎移植（FET）周期中血清雌二醇（E-2）水平与持续妊娠/活产率（OP/LB）的相关性。在学术环境下进行了一项历史队列研究，目的是将2011年1月至2014年12月进行的所有自体人工冷冻胚胎移植周期中雌二醇峰值和平均水平与妊娠/活产率之间的关系联系起来。分析95例患者110个自体人工FET周期的平均和峰值E-2水平。在导致OP/LB的循环中，平均E-2水平显著低于未导致OP/LB的循环（分别为234.1 +/- 16.6 pg/ml和315 +/- 24.8 pg/ml, p = 0.04）。虽然E-2峰值水平在导致OP/LB的周期与未发生OP/LB的周期之间没有显著差异（分别为366.9 +/- 27.7 pg/ml vs. 459.1 +/- 32.3 pg/ml, p = 0.19），但相关分析显示，随着E-2峰值水平的升高，OP/LB率呈显著下降趋势（p = 0.02）。本研究表明，人工自体FET周期中E-2水平升高与OP/LB发生率降低相关。在人工FET周期中应监测雌二醇水平。
The aim of this study is to evaluate the correlation between serum estradiol (E-2) levels during artificial autologous frozen embryo transfer (FET) cycles and ongoing pregnancy/live birth rates (OP/LB).A historical cohort study was conducted in an academic setting in order to correlate peak and average estradiol levels with ongoing pregnancy/live birth rates for all autologous artificial frozen embryo transfer cycles performed from 1/2011 to 12/2014.Average and peak E-2 levels from 110 autologous artificial FET cycles from 95 patients were analyzed. Average E-2 levels were significantly lower in cycles resulting in OP/LB compared to those that did not (234.1 +/- 16.6 pg/ml vs. 315 +/- 24.8 pg/ml, respectively, p = 0.04). Although peak E-2 levels were not significantly different between cycles resulting in OP/LB compared with those that did not (366.9 +/- 27.7 pg/ml vs. 459.1 +/- 32.3 pg/ml, respectively, p = 0.19), correlation analysis revealed a statistically significant (p = 0.02) downward trend in OP/LB rates with increasing peak E-2 levels.This study suggests that elevated E-2 levels in artificial autologous FET cycles are associated with lower OP/LB rates. Estradiol levels should be monitored during artificial FET cycles.