IMMEDIATE INVIVO EFFECT OF CORTICOSTERONE ON GLUCOSE-INDUCED INSULIN-SECRETION IN THE RAT
IMMEDIATE INVIVO EFFECT OF CORTICOSTERONE ON GLUCOSE-INDUCED INSULIN-SECRETION IN THE RAT
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DOI：
10.1677/joe.0.0950315
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发表时间：
1982-01-01
影响因子：
4
通讯作者：
SUTTER, BCJ
中科院分区：
文献类型：
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作者：
BILLAUDEL, B;SUTTER, BCJ
当葡萄糖浓度为基础时，在通过调节的葡萄糖输注获得的标准葡萄糖水平下以及响应于标准或调节的葡萄糖脉冲时，检查输注的皮质酮（300 μ g/h/kg体重）对大鼠血浆中胰岛素浓度的影响。当葡萄糖浓度为基础或响应于标准葡萄糖脉冲而升高时，皮质酮对血浆胰岛素水平没有影响。当输注葡萄糖时，当糖皮质激素存在时，60分钟后检测到胰岛素的血浆水平显著降低，并且在葡萄糖的调制脉冲后该水平保持显著降低。皮质酮的输注导致血浆中胰岛素浓度的急性降低，并且仅当激素在血浆中存在胰岛素刺激性葡萄糖浓度的情况下起作用时，才导致胰岛素对葡萄糖脉冲的响应的急性降低。
The effect of infused corticosterone (300 .mu.g/h per kg body wt) on the concentrations of insulin in the plasma of the rat was examined when glucose concentration was basal, at standardized glucose levels attained by modulated glucose infusion and in response to a standard or a modulated glucose pulse. There was no effect of corticosterone on the levels of plasma insulin when the glucose concentrations were either basal or raised in response to the standard pulse of glucose. When glucose was infused a significantly reduced plasma level of insulin was detected after 60 min when the glucocorticoid was present and this level remained significantly reduced after the modulated pulse of glucose. The infusion of corticosterone leads to an acute depression of the concentrations of insulin in the plasma and of their response to a glucose pulse only when the hormone acts in the presence of a concentration of glucose in the plasma that is insulin-stimulatory.