Neuron-specific enolase is unaltered whereas S100B is elevated in serum of patients with schizophrenia - Original research and meta-analysis
Neuron-specific enolase is unaltered whereas S100B is elevated in serum of patients with schizophrenia - Original research and meta-analysis
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DOI：
10.1016/j.psychres.2008.01.002
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发表时间：
2009-05-15
影响因子：
11.3
通讯作者：
Blasig, Ingolf E.
中科院分区：
文献类型：
--
作者：
Schroeter, Matthias L.;Abdul-Khaliq, Hashim;Blasig, Ingolf E.
先前的研究报告了精神分裂症患者星形胶质细胞标志物S100B水平的改变。为了阐明机制，我们每周测量20例精神分裂症患者和19名年龄和性别匹配的对照组的血清S100 B水平以及神经元标记物神经元特异性烯醇化酶。与对照组相比，精神分裂症患者入院和出院时S100 B升高，而神经元特异性烯醇化酶无显著差异。治疗对S100 B或神经元特异性烯醇化酶均无影响。一项对所有已发表的研究进行的系统性定量荟萃分析，涉及380例患者和358例对照受试者，结果显示精神分裂症患者血清S100 B升高，而抗精神病药物治疗无任何影响。结果提示，精神分裂症患者血清S100 B水平升高与星形胶质细胞主动分泌S100 B及血脑屏障功能障碍有关。(C)2008爱思唯尔爱尔兰有限公司保留所有战斗。
Previous studies reported altered levels of the astrocytic marker S100B in schizophrenia. To clarify mechanisms, we measured weekly serum levels of S100B together with the neuronal marker neuron-specific enolase in 20 patients with schizophrenia and 19 age- and gender-matched control subjects. S100B was elevated at admission and discharge in schizophrenic patients compared with control subjects, whereas there were no significant differences for neuron-specific enolase. Treatment had no impact on either S100B or neuron-specific enolase. A systematic, quantitative meta-analysis of all published studies involving 380 patients and 358 control subjects revealed elevated serum S100B in schizophrenia without any effect of antipsychotic treatment. Results suggest that increases of serum S100B are related to active secretion of S100B by astrocytes in combination with blood-brain barrier dysfunction in schizophrenia. (C) 2008 Elsevier Ireland Ltd. All fights reserved.