Plasminogen activator inhibitor-1 activity is independently related to both insulin sensitivity and serum triglycerides in 70-year-old men
Plasminogen activator inhibitor-1 activity is independently related to both insulin sensitivity and serum triglycerides in 70-year-old men
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DOI：
10.1161/01.atv.18.2.258
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发表时间：
1998-02-01
影响因子：
8.7
通讯作者：
Lithell, H
中科院分区：
文献类型：
--
作者：
Byberg, L;Siegbahn, A;Lithell, H
纤溶酶原激活物抑制剂-1（派-1）水平升高已被讨论为胰岛素抵抗综合征的一部分。然而，尚不清楚派-1和胰岛素抵抗之间的关系是否独立于或由增加的甘油三酯水平介导。本研究的目的是研究派-1活性是否与胰岛素敏感性相关，而独立于血清甘油三酯（sTG）和其他潜在的混杂因素。取血样测定派-1活性。胰岛素敏感性通过正葡萄糖高胰岛素钳夹测定。在多变量相关和回归分析中，胰岛素敏感性是派-1活性的统计学显著决定因素（部分r=-.12，P
Increased levels of plasminogen activator inhibitor-1 (PAI-1) have been discussed as a part of the insulin resistance syndrome. However, it is not clear whether the relationship between PAI-1 and insulin resistance is independent of or mediated by increased triglycerides levels, The aim of this study was to investigate whether PAI-1 activity is associated with insulin sensitivity independently of serum triglycerides (sTG) and of other potential confounders, Seventy year old men (n=871), participating in a cohort study undergoing extensive metabolic investigations, had blood samples taken for determination of PAI-1 activity. Insulin sensitivity was determined by the euglycemic hyperinsulinemic clamp. In multivariate correlation and regression analyses, insulin sensitivity was a statistically significant determinant of PAI-1 activity (partial r=-.12, P