Familial prostatic cancer risk and low testosterone.
Familial prostatic cancer risk and low testosterone.
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家族性前列腺癌风险和低睾酮水平。
DOI：
10.1210/jcem-54-6-1104
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发表时间：
1982
期刊：
影响因子：
--
通讯作者：
W. Stanish
中科院分区：
文献类型：
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作者：
A. W. Meikle;W. Stanish
我们调查了家族因素是否影响1）前列腺癌的发病率和2）性类固醇的血浆含量。在犹他州的一般人群中，观察到前列腺癌病例（n = 150）的兄弟（n = 257）发生前列腺癌的相对风险是其姐夫（n = 202）和男性的4倍。血浆睾酮含量[组内相关系数（r1）= 0.51; P <0.01]和表观游离睾酮浓度（r1 = 0.54; P <0.01）的组内相关性在非内分泌治疗病例及其兄弟中非常显著。此外，儿子和他们的父亲在血浆二氢睾酮（r1 = 0.83; P <0.01）和睾酮与二氢睾酮的比值（r1 = 0.46; P <0.05）方面具有显著的组内相关性。先证者和他们的兄弟，以及患有这种疾病的患者的儿子的血浆睾酮水平明显低于同龄对照组。这是第一个文件表明，家族（可能是遗传）因素是潜在的危险因素，使男性患前列腺癌的发展和调节血浆中的雄激素含量。我们的研究结果表明，血浆雄激素水平在前列腺癌的家庭聚集在正常人群的较低范围。他们还表明，血浆雄激素含量在每个癌症家庭中比在没有癌症的家庭中更相似。
We investigated whether familial factors influence 1) the incidence of prostatic cancer and 2) the plasma content of sex steroids. A 4-fold higher relative risk for the development of prostatic cancer was observed for brothers (n = 257) of prostatic cancer cases (n = 150) compared to their brothers-in-law (n = 202) and males in the general population of the state Utah. The intraclass correlation for plasma testosterone content [intraclass correlation coefficient (r1) = 0.51; P less than 0.01] and the apparent free testosterone concentration (r1 = 0.54; P less than 0.01) were highly significant in nonendocrinologically treated cases and their brothers. Further, sons and their fathers had significant intraclass correlations for both plasma dihydrotesterone (r1 = 0.83; P less than 0.01) and the ratio of testosterone to dihydrotestosterone (r1 = 0.46; P less than 0.05). Probands and their brothers, and sons of the patients with the disease had significantly lower plasma testosterone levels than controls of comparable age. This is the first documentation indicating that familial (possibly genetic) factors are potent risk factors for predisposing men to the development of prostatic cancer and in regulating the plasma content of androgens. Our results indicate that plasma androgen levels in families with prostatic cancer are clustered in the lower range of the normal population. They also suggest that plasma androgen content is more similar within each family with the cancer than among the families without cancer.