Synergism and mutualism in non-enzymatic RNA polymerization.
Synergism and mutualism in non-enzymatic RNA polymerization.
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DOI：
10.3390/life4040598
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发表时间：
2014-11-03
期刊：
影响因子：
--
通讯作者：
Sahai N
中科院分区：
文献类型：
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作者：
Kaddour H;Sahai N
非酶RNA聚合和RNA自我复制之间的联系是迈向“RNA世界”的关键一步，尽管进行了广泛的研究，但仍远未解决。粘土矿物、脂类和最近的多肽被发现催化RNA寡聚体的非酶合成。在此，对第一批RNA聚合物形成的主要模型进行了综述，强调了生命构件之间在它们的出现和进化过程中的合作。先前结果的一个合乎逻辑的结果是这些模型的组合，其中RNA聚合可能是在一个多组分的益生菌汤中由粘土、脂类和多肽协同催化的。由此产生的RNA和寡肽可能在第一次RNA复制之前相互进化为功能RNA和催化肽，从而支持RNA-肽世界。这种体系的研究是一项艰巨的挑战，因为它的复杂性来自于大量的反应物和无数的产品。概述了一个初步的实验设计，可用于研究四元组分系统的初步尝试。
The link between non-enzymatic RNA polymerization and RNA self-replication is a key step towards the “RNA world” and still far from being solved, despite extensive research. Clay minerals, lipids and, more recently, peptides were found to catalyze the non-enzymatic synthesis of RNA oligomers. Herein, a review of the main models for the formation of the first RNA polymers is presented in such a way as to emphasize the cooperation between life’s building blocks in their emergence and evolution. A logical outcome of the previous results is a combination of these models, in which RNA polymerization might have been catalyzed cooperatively by clays, lipids and peptides in one multi-component prebiotic soup. The resulting RNAs and oligopeptides might have mutualistically evolved towards functional RNAs and catalytic peptides, preceding the first RNA replication, thus supporting an RNA-peptide world. The investigation of such a system is a formidable challenge, given its complexity deriving from a tremendously large number of reactants and innumerable products. A rudimentary experimental design is outlined, which could be used in an initial attempt to study a quaternary component system.