Efficacy of single-dose and triple-dose albendazole and mebendazole against soil-transmitted helminths and Taenia spp.: a randomized controlled trial.
Efficacy of single-dose and triple-dose albendazole and mebendazole against soil-transmitted helminths and Taenia spp.: a randomized controlled trial.
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DOI：
10.1371/journal.pone.0025003
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发表时间：
2011
期刊：
影响因子：
3.7
通讯作者：
Zhou XN
中科院分区：
文献类型：
--
作者：
Steinmann P;Utzinger J;Du ZW;Jiang JY;Chen JX;Hattendorf J;Zhou H;Zhou XN
土源性蠕虫（STH）感染的控制目前依赖于单剂量口服阿苯达唑或甲苯达唑的大规模给药。然而，这些治疗方案在治愈率（CR）方面对钩虫和鞭虫的疗效有限，而粪便虫卵减少率（ERR）对于所有常见的STH物种通常都很高。我们在中华人民共和国进行的一项基于社区的随机对照试验中比较了单剂量与三剂量治疗对钩虫和其他STH的疗效。在314名年龄≥5岁的个体中评估了钩虫CR和粪便ERR，这些个体在单剂量口服阿苯达唑（400 mg）或甲苯达唑（500 mg）或三剂量阿苯达唑（3×400 mg连续3天）或甲苯达唑（3×500 mg连续3天）给药前和给药后3-4周提交了两份粪便样本。对T.鞭虫属、蛔虫属和带绦虫属。也进行了评估。在两种治疗方案中，阿苯达唑治愈的钩虫感染显著多于甲苯达唑（单次给药：CR分别为69%（95%置信区间[CI]：55-81%）和29%（95% CI：20-45%）;三次给药：CR分别为92%（95% CI：81-98%）和54%（95% CI：46-71%））。ERRs遵循相同的模式（单次给药：97% vs 84%;三次给药：99.7% vs 96%）。三剂量方案优于单剂量对T。三剂甲苯咪唑-最有效的治疗测试-治愈71%（95% CI：57-82%）。两种药物的单次和三次给药均对A.蛔虫（CR：93-97%; ERR：均>99.9%）。三倍剂量方案治愈了所有带绦虫属。感染，而单剂量应用仅治愈了其中的一半。单剂量口服阿苯达唑治疗钩虫比甲苯达唑更有效。为了达到高CR对钩虫和T。三剂量疗法是必要的 www.controlled-trials.com www.example.com
The control of soil-transmitted helminth (STH) infections currently relies on the large-scale administration of single-dose oral albendazole or mebendazole. However, these treatment regimens have limited efficacy against hookworm and Trichuris trichiura in terms of cure rates (CR), whereas fecal egg reduction rates (ERR) are generally high for all common STH species. We compared the efficacy of single-dose versus triple-dose treatment against hookworm and other STHs in a community-based randomized controlled trial in the People's Republic of China. The hookworm CR and fecal ERR were assessed in 314 individuals aged ≥5 years who submitted two stool samples before and 3–4 weeks after administration of single-dose oral albendazole (400 mg) or mebendazole (500 mg) or triple-dose albendazole (3×400 mg over 3 consecutive days) or mebendazole (3×500 mg over 3 consecutive days). Efficacy against T. trichiura, Ascaris lumbricoides, and Taenia spp. was also assessed. Albendazole cured significantly more hookworm infections than mebendazole in both treatment regimens (single dose: respective CRs 69% (95% confidence interval [CI]: 55–81%) and 29% (95% CI: 20–45%); triple dose: respective CRs 92% (95% CI: 81–98%) and 54% (95% CI: 46–71%)). ERRs followed the same pattern (single dose: 97% versus 84%; triple dose: 99.7% versus 96%). Triple-dose regimens outperformed single doses against T. trichiura; three doses of mebendazole – the most efficacious treatment tested – cured 71% (95% CI: 57–82%). Both single and triple doses of either drug were highly efficacious against A. lumbricoides (CR: 93–97%; ERR: all >99.9%). Triple dose regimens cured all Taenia spp. infections, whereas single dose applications cured only half of them. Single-dose oral albendazole is more efficacious against hookworm than mebendazole. To achieve high CRs against both hookworm and T. trichiura, triple-dose regimens are warranted. www.controlled-trials.com ISRCTN47375023
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