Cord Blood Vitamin D and Neurocognitive Development Are Nonlinearly Related in Toddlers
Cord Blood Vitamin D and Neurocognitive Development Are Nonlinearly Related in Toddlers
复制标题
幼儿的脐带血维生素 D 和神经认知发育呈非线性相关。
DOI：
10.3945/jn.114.208801
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发表时间：
2015-06-01
影响因子：
4.2
通讯作者：
Tao, Fang-Biao
中科院分区：
文献类型：
--
作者：
Zhu, Peng;Tong, Shi-Lu;Tao, Fang-Biao
背景资料：研究目的：探讨出生时脐带血25-羟基维生素D（25（OH）D）水平与婴幼儿神经认知发育的关系。方法：作为中国安徽省出生队列研究的一部分，选取363对资料完整的母婴对。放射免疫法测定脐血25（OH）D浓度。采用Bayley婴儿发育量表对16-18月龄幼儿的智力发育指数（MDI）和精神发育指数（PDI）进行评定。结果：脐血25（OH）D水平最低的幼儿，其25（OH）D水平较对照组低7.60与参考类别相比，MDI和PDI评分分别为8.04分（95% CI：-12.4，-2.82; P= 0.002）和8.04分（95% CI：-12.9，-3.11; P = 0.001）。出乎意料的是，在最高的五分之一的脐带血25（OH）D的幼儿也有一个显着的赤字12.3（95%CI：-17.9，-6.67; P < 0.001）点的PDI分数与参考category.Conclusions相比：这项前瞻性研究表明，有一个倒U形的关系新生儿维生素D的状态和神经认知发育的幼儿。需要对生命早期的最佳25（OH）D浓度进行进一步研究。
Background: Little is known about the relation between vitamin D status in early life and neurodevelopment outcomes.Objective: This study was designed to examine the association of cord blood 25-hydroxyvitamin D [25(OH)D] at birth with neurocognitive development in toddlers.Methods: As part of the China-Anhui Birth Cohort Study, 363 mother-infant pairs with complete data were selected. Concentrations of 25(OH)D in cord blood were measured by radioimmunoassay. Mental development index (MDI) and psychomotor development index (PDI) in toddlers were assessed at age 16-18 mo by using the Bayley Scales of Infant Development. The data on maternal sociodemographic characteristics and other confounding factors were also prospectively collected.Results: Toddlers in the lowest quintile of cord blood 25(OH)D exhibited a deficit of 7.60 (95% CI: -12.4, -2.82; P= 0.002) and 8.04 (95% CI: -12.9, -3.11; P = 0.001) points in the MDI and PDI scores, respectively, compared with the reference category. Unexpectedly, toddlers in the highest quintile of cord blood 25(OH)D also had a significant deficit of 12.3 (95% CI: -17.9, -6.67; P < 0.001) points in PDI scores compared with the reference category.Conclusions: This prospective study suggested that there was an inverted-U-shaped relation between neonatal vitamin D status and neurocognitive development in toddlers. Additional studies on the optimal 25(OH)D concentrations in early life are needed.