microRNA-214 contributes to melanoma tumour progression through suppression of TFAP2C
microRNA-214 contributes to melanoma tumour progression through suppression of TFAP2C
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DOI：
10.1038/emboj.2011.102
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发表时间：
2011-05-18
期刊：
影响因子：
11.4
通讯作者：
Taverna, Daniela
中科院分区：
文献类型：
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作者：
Penna, Elisa;Orso, Francesca;Taverna, Daniela
恶性黑色素瘤在其转移阶段是致命的。因此，有必要阐明控制疾病进展至转移的分子机制。microRNA（miRs）是参与肿瘤发生的内源性非编码RNA。使用黑色素瘤进展模型，我们确定了一种由miR-214控制的协调转移能力的新途径。途径成分包括TFAP 2C，一种成熟的黑色素瘤肿瘤抑制因子的同源物，粘附受体ITGA 3和多种表面分子。miR-214的调节影响体外肿瘤细胞运动和存活至失巢凋亡以及体内从血管外渗和肺转移形成。考虑到已知miR-214在人类黑色素瘤中高度表达，我们的数据表明该miRNA在疾病进展和远处转移的建立中起关键作用。EMBO期刊（2011）30，1990-2007。doi：10.1038/daj.2011.102; 2011年4月5日在线发布
Malignant melanoma is fatal in its metastatic stage. It is therefore essential to unravel the molecular mechanisms that govern disease progression to metastasis. MicroRNAs (miRs) are endogenous non-coding RNAs involved in tumourigenesis. Using a melanoma progression model, we identified a novel pathway controlled by miR-214 that co-ordinates metastatic capability. Pathway components include TFAP2C, homologue of a well-established melanoma tumour suppressor, the adhesion receptor ITGA3 and multiple surface molecules. Modulation of miR-214 influences in vitro tumour cell movement and survival to anoikis as well as extravasation from blood vessels and lung metastasis formation in vivo. Considering that miR-214 is known to be highly expressed in human melanomas, our data suggest a critical role for this miRNA in disease progression and the establishment of distant metastases. The EMBO Journal (2011) 30, 1990-2007. doi: 10.1038/emboj.2011.102; Published online 5 April 2011