Low D2-40 immunoreactivity correlates with lymphatic invasion and nodal metastasis in early-stage squamous cell carcinoma of the uterine cervix
Low D2-40 immunoreactivity correlates with lymphatic invasion and nodal metastasis in early-stage squamous cell carcinoma of the uterine cervix
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DOI：
10.1038/modpathol.3800269
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发表时间：
2005-01-01
期刊：
影响因子：
7.5
通讯作者：
Acs, G
中科院分区：
文献类型：
--
作者：
Dumoff, KL;Chu, C;Acs, G
宫颈癌的淋巴浸润和淋巴结转移是无病生存期和总生存期较短的预测因素。单克隆抗体D2-40可与癌胚膜抗原M2 A反应，是一种新的淋巴管内皮选择性标记物，并已被证明可用于识别包括宫颈癌在内的各种恶性肿瘤中淋巴管浸润的存在。然而，尚未评价肿瘤细胞与D2-40的反应性。在这项研究中，我们研究了138例宫颈浸润性鳞状细胞癌中D2-40免疫反应的模式。我们将肿瘤细胞中D2-40免疫反应性的存在和程度与各种临床病理特征、淋巴浸润的存在、淋巴结转移和结果相关联。弥漫性或局灶性D2-40免疫反应分别出现在17例（12%）和81例（59%）肿瘤中，而40例（29%）肿瘤显示无免疫反应。淋巴管浸润和淋巴结转移分别占56%和29%。淋巴间隙内的肿瘤栓子和淋巴结内的转移性肿瘤病灶分别在86和80%的病例中显示无免疫反应性。D2-40免疫反应性低的肿瘤中淋巴结浸润和淋巴结转移明显更常见（P
Lymphatic invasion and nodal metastasis are predictors of shorter disease-free and overall survival in carcinoma of the uterine cervix. The monoclonal antibody D2-40, which reacts with the oncofetal membrane antigen M2A, is a new selective marker for lymphatic endothelium, and has been shown to be useful in identifying the presence of lymphatic invasion in various malignant neoplasms, including cervical carcinoma. However, the reactivity of the tumor cells with D2-40 has not yet been evaluated. In this study, we examined the pattern of D2-40 immunoreactivity in a series of 138 invasive squamous cell carcinomas of the uterine cervix. We correlated the presence and extent of D2-40 immunoreactivity in the tumor cells with various clinicopathologic features, the presence of lymphatic invasion, lymph node metastasis and outcome. Diffuse or focal D2-40 immunoreactivity was present in 17 (12%) and 81 (59%) tumors, respectively, while 40 (29%) tumors showed no immunoreactivity. Lymphatic invasion and nodal metastasis were present in 56 and 29% of tumors, respectively. Tumor emboli within lymphatic spaces and metastatic tumor foci in lymph nodes showed no immunoreactivity in 86 and 80% of the cases, respectively. Lymphatic invasion and nodal metastasis were significantly more common in tumors showing low D2-40 immunoreactivity ( P