Clinicopathological characteristics of distant metastases of adenocarcinoma, squamous cell carcinoma and urothelial carcinoma : An autopsy study of older Japanese patients.
Clinicopathological characteristics of distant metastases of adenocarcinoma, squamous cell carcinoma and urothelial carcinoma : An autopsy study of older Japanese patients.
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腺癌、鳞状细胞癌和尿路上皮癌远处转移的临床病理学特征：对日本老年患者的尸检研究。
DOI：
10.1111/ggi.13165
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发表时间：
2018
期刊：
影响因子：
--
通讯作者：
Arai T.
中科院分区：
文献类型：
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作者：
Matsuda Y;Seki A;Nonaka K;Kakizaki M;Wang T;Aida J;Ishikawa N;Nakano Y;Kaneda D;Takata T;Takahashi-Fujigasaki J;Murayama S;Takubo K;Ishiwata T;Sawabe M;Arai T.
目的明确老年人全身恶性肿瘤的特点，重点关注全身远处转移。方法对7710例尸检病例（男性4011例，女性3699例，中位年龄80岁）进行回顾性分析，分析腺癌、鳞状细胞癌和尿路上皮癌各脏器的转移特征。结果腺癌、鳞状细胞癌总例数尿路上皮癌2856例，其中以腺癌为主。其中，1604例有转移病灶，且转移患者较未转移患者年龄年轻。腺癌的主要原发器官是胃、结肠、肺、前列腺、胆囊和胰腺，而鳞状细胞癌的主要原发器官是肺、食道和子宫。膀胱、肾脏和输尿管均发现尿路上皮癌病例。转移性腺癌主要起源于胃、结肠、肺、胰腺和胆囊。转移性鳞状细胞癌来自肺、食道和子宫，而肾、膀胱和输尿管是转移性尿路上皮癌的主要起源。鳞状细胞癌的转移发生率最高，表明其具有侵袭性表型。此外，不同主要器官的转移能力和首选转移部位也不同。结论我们在对来自一个机构的老年日本患者进行的一项大规模尸检研究中揭示了转移癌的准确发病率和特征。识别这些特征可能会促进恶性肿瘤筛查，从而提高老年人的生活质量。Geriatr Gerontol Int 2018； 18：211-215。
AimWe aimed to clarify the characteristics of malignancies in older adults focusing on distant metastasis in the whole body.MethodsWe retrospectively evaluated 7710 cases of autopsies (4011 men, 3699 women, median age of 80 years), and analyzed the characteristics of metastasis of adenocarcinoma, squamous cell carcinoma and urothelial carcinoma in each organ.ResultsThe total number of cases with adenocarcinoma, squamous cell carcinoma or urothelial carcinoma was 2856, and most of them were adenocarcinomas. Among them, 1604 had metastatic lesions, and patients with metastasis were younger than those without metastasis. The major primary organs of adenocarcinoma were the stomach, colon, lung, prostate, gallbladder and pancreas, whereas those for squamous cell carcinoma were the lung, esophagus and uterus. Urothelial carcinoma cases were found in the urinary bladder, kidney and ureter. Metastatic adenocarcinomas mainly originated from the stomach, colon, lung, pancreas and gallbladder. Metastatic squamous cell carcinomas were from the lung, esophagus and uterus, whereas the kidney, bladder and ureter were the primary origins of metastatic urothelial carcinomas. Squamous cell carcinoma showed the highest incidence of metastasis, suggestive of it being of an aggressive phenotype. Furthermore, metastatic ability and the preferred metastatic sites varied among primary organs.ConclusionsWe revealed an accurate incidence and the characteristics of metastatic cancer in a large‐scale autopsy study of older Japanese patients from one institution. Identifying these features might prompt screening for malignancies, and consequently improve quality of life for older adults.Geriatr Gerontol Int 2018; 18: 211–215.