Genomic organization of human TCF12 gene and spliced mRNA variants producing isoforms of transcription factor HTF4
Genomic organization of human TCF12 gene and spliced mRNA variants producing isoforms of transcription factor HTF4
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DOI：
10.1159/000071042
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发表时间：
2002-01-01
影响因子：
1.7
通讯作者：
Bina, M
中科院分区：
文献类型：
--
作者：
Gan, TI;Rowen, L;Bina, M
人类TCF 12基因定位于15 q21，编码螺旋-环-螺旋转录因子4（HTF 4）。对该基因组区域的详细分析建立了TCF 12基因的组织。该基因包括21个外显子，明显大于平均人类基因。在第二个外显子之前，两个用于mRNA剪接的替代受体位点产生两个可区分的转录物（HTF 4a和HTF 4 b），其5'非翻译区不同，但共享相同的编码序列。TCF 12基因外显子15的差异利用可能反映了产生细胞类型特异性蛋白（HTF 4c）的机制。此外，TCF 12基因中的内含子5对应于涉及易位t（9;15）（q22;q21）的区域，该易位导致一种形式的皮肤外粘液样软骨肉瘤。版权所有（C）2002 S. Karger AG，巴塞尔。
The human TCF12 gene, mapping to 15q21, encodes the helix-loop-helix transcription factor 4 (HTF4). A detailed analysis of this genomic region established the organization of the TCF12 gene. The gene includes 21 exons and is significantly larger than an average human gene. Preceding the second exon, two alternative acceptor sites for mRNA splicing yield two distinguishable transcripts (HTF4a and HTF4b) which differ in their 5' untranslated region but share identical coding sequences. Differential utilization of exon 15 in the TCF12 gene may reflect a mechanism producing a cell-type-specific protein (HTF4c). In addition, intron 5 in the TCF12 gene corresponds to the region involved in a translocation, t(9;15)(q22;q21), that results in a form of extraskeletal myxoid chondrosarcoma. Copyright (C) 2002 S. Karger AG, Basel.