Protein kinase C blockers and neutrophil receptors for leukotriene B4.
Protein kinase C blockers and neutrophil receptors for leukotriene B4.
复制标题
蛋白激酶 C 阻滞剂和白三烯 B4 的中性粒细胞受体。
DOI：
10.1016/0006-291x(89)91142-x
复制
发表时间：
1989
影响因子：
3.1
通讯作者：
Jacobson,D
中科院分区：
文献类型：
--
作者：
O'Flaherty,JT;Jacobson,D
Three protein kinase C blockers (staurosporin, Cl, and sphinganine) acted temperature- and time-dependently on human neutrophils to lower the affinity and number of high affinity plasmalemma receptors available to leukotriene B4. The drugs did not alter the ligand's binding to isolated plasma membranes or reduce intact cell binding of platelet-activating factor. Thus, protein kinase C may regulate the expression of certain receptors in resting cells and blockers of this enzyme, by interfering with receptor expression, have secondary effects that complicate their use as pharmacological probes.
