Tissue-engineering strategies for the tendon/ligament-to-bone insertion.
Tissue-engineering strategies for the tendon/ligament-to-bone insertion.
复制标题
肌腱/韧带至骨插入的组织工程策略。
DOI：
10.3109/03008207.2011.650804
复制
发表时间：
2012
影响因子：
2.9
通讯作者：
Thomopoulos S
中科院分区：
文献类型：
--
作者：
Smith L;Xia Y;Galatz LM;Genin GM;Thomopoulos S
结缔组织的损伤是痛苦和致残的，并导致昂贵的医疗费用。这些损伤通常需要将未矿化的结缔组织重新附着到骨上。未受伤的肌腱/韧带-骨插入（附着点）是一种功能梯度材料，其表现出从软组织（即，肌腱或韧带）到硬组织（即，矿化骨）通过纤维软骨过渡区。这种转变被认为通过改善潜在的破坏性界面应力集中来促进两种不同组织之间的力传递。过渡区在肌腱/韧带损伤时受损或丢失，并且在手术修复或自然愈合后不能再生，使组织暴露于再损伤的风险中。需要再生一个强大的肌腱-骨插入导致了许多组织工程修复策略。这篇综述将肌腱-骨插入部位视为一种组织结构，其主要作用是机械性的，并讨论了在这种情况下工程化肌腱/韧带-骨插入的当前和新兴策略。重点在于生产的机械结构，可以引导和随后维持一个分级的组织结构和相关的细胞群的策略。
Injuries to connective tissues are painful and disabling and result in costly medical expenses. These injuries often require re-attachment of an unmineralized connective tissue to bone. The uninjured tendon/ligament-to-bone insertion (enthesis) is a functionally graded material that exhibits a gradual transition from soft tissue (i.e., tendon or ligament) to hard tissue (i.e., mineralized bone) through a fibrocartilaginous transition region. This transition is believed to facilitate force transmission between the two dissimilar tissues by ameliorating potentially damaging interfacial stress concentrations. The transition region is impaired or lost upon tendon/ligament injury and is not regenerated following surgical repair or natural healing, exposing the tissue to risk of re-injury. The need to regenerate a robust tendon-to-bone insertion has led a number of tissue engineering repair strategies. This review treats the tendon-to-bone insertion site as a tissue structure whose primary role is mechanical and discusses current and emerging strategies for engineering the tendon/ligament-to-bone insertion in this context. The focus lies on strategies for producing mechanical structures that can guide and subsequently sustain a graded tissue structure and the associated cell populations.