'Omic' and hypothesis-driven research in the molecular pharmacology of cancer
'Omic' and hypothesis-driven research in the molecular pharmacology of cancer
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DOI：
10.1016/s1471-4892(02)00185-6
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发表时间：
2002-08-01
影响因子：
4
通讯作者：
Weinstein, JN
中科院分区：
文献类型：
--
作者：
Weinstein, JN
考虑到生物系统的分层和进化的复杂性，仅仅基于假设驱动的研究不可能全面理解它们。同样，仅仅通过对基因、蛋白质和其他分子的“组学”研究也不可能做到这一点。这两种研究模式是互补和协同的。癌症生物学和药物发现的双重复杂性需要这种协同作用作为下一代肿瘤药物组学研究的基础。
Given the layered, evolutionary complexity of biological systems, it will not be possible to understand them comprehensively on the basis of hypothesis-driven research alone. Likewise, it will not be possible to do so solely through 'omic' studies of genes, proteins and other molecules in aggregate. The two modes of research are complementary and synergistic. The twin complexities of cancer biology and drug discovery demand such synergy as a basis for the next generation of oncopharmacomic research.