A pilot study: Innate immune modulation reduces F2-Isoprostanes and improves psychological health in a chronically stressed cohort.
A pilot study: Innate immune modulation reduces F2-Isoprostanes and improves psychological health in a chronically stressed cohort.
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一项初步研究：先天免疫调节降低f2 -异前列腺素并改善慢性应激人群的心理健康。
DOI：
10.1002/hsr2.289
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发表时间：
2021-06
影响因子：
2
通讯作者：
Jones BA
中科院分区：
文献类型：
--
作者：
Finley KD;Marcellus JE;Jones BA
氧化应激（OS）已成为生物系统的问题，由于与复杂的细胞氧化还原过程相关的自由基的产生增加。此外，OS与先天免疫系统的异常激活相关，导致全身炎症或应激。3大量研究集中在全身OS上，其与多种疾病状态和急性应激条件的相关性是众所周知的。4-6然而，关于降低人体全身OS水平的研究在很大程度上是不确定的，因为它们依赖于外源性治疗，如抗氧化剂和益生菌。7-9由于全身OS涉及免疫系统，因此潜在策略将涉及开发促进免疫平衡的靶向治疗，从而有助于内源性降低总体OS特征。10，11最近，通过果蝇体内研究已经证明，无活性细菌生物制剂（IA B），伴随着确认的病原体分子相关模式（PAMP）选择Toll样受体（TLR）和含核苷酸结合寡聚化结构域蛋白（NOD）受体，降低了NF-κ B信号级联的炎症靶标。12进行初步研究以使用OS生物标志物尿F2-异前列烷（F2-IsoP）确定口服施用IAB对人体全身OS水平的影响。F2-IsoP是一种稳定的非侵入性生物标志物和前列腺素氧化的终末期代谢产物，存在于所有体液和组织中，据报道在氧化损伤期间增加（马约诊所实验室;克利夫兰心脏实验室公司）。1，2，13这使得F2-IsoP比传统的血浆应激生物标志物更有优势。本报告描述了接受IAB治疗的创伤后应激障碍退伍军人应激队列中尿F2-IsoP水平和心理健康参数的变化。
Oxidative stress (OS) has become problematic for the biological systems owing to the elevated production of free radicals associated with complex cellular redox processes. 1, 2 Furthermore, OS is associated with the aberrant activation of the innate immune system leading to systemic inflammation or stress. 3 Considerable research has been focused on the systemic OS, and its correlation with multiple disease states and acute stress conditions is well-known. 4-6 However, the studies that address lowering the systemic OS levels in humans have been largely inconclusive as they depend on exogenous treatments, such as antioxidants and probiotics. 7-9 Since systemic OS involves the immune system, a potential strategy would involve the development of a targeted treatment that promotes immune balance, thereby helping to lower the global OS profiles endogenously. 10, 11 Recently, it has been demonstrated through in vivo Drosophila studies that an inactive bacterial biologic (IAB), accompanied with confirmed pathogen molecular associated patterns (PAMPs) to select Toll-like receptors (TLR) and nucleotide-binding oligomerization domain-containing protein (NOD) receptors, lowered the inflammatory targets of the NF-κB signaling cascade. 12 A pilot study was conducted to determine the effect of oral administration of IAB on the systemic OS levels in humans using the OS biomarker, urinary F2-isoprostane (F2-IsoP). F2-IsoP is a stable noninvasive biomarker and an end-stage metabolite of prostaglandin oxidation, present in all fluids and tissues, and has been reported to increase during the oxidative injury (Mayo Clinic Labs; Cleveland Heart Lab, Inc.). 1, 2, 13 This allows F2-IsoP to be more advantageous than traditional plasma stress biomarkers. This report describes the changes in urinary F2-IsoP levels as well as mental health parameters in a stressed cohort of PTSD combat veterans who received IAB treatment.