Core outcome sets and core outcome measures: a primer
Core outcome sets and core outcome measures: a primer
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DOI：
10.1007/s00403-020-02159-x
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发表时间：
2020-11-18
影响因子：
3
通讯作者：
Maher, Ian A.
中科院分区：
文献类型：
--
作者：
Alam, Murad;Ibrahim, Sarah A.;Maher, Ian A.
许多关于针对特定患者问题的最佳治疗方法的问题仍有待回答。解决这些问题的临床试验可能无法获得。如果是这样的话，这些试验可能会因为更大的多中心试验的费用和后勤复杂性而动力不足。在荟萃分析中汇集相同疗法或干预措施的小规模试验结果也可能是令人担忧的。通常，这样的试验评估的结果略有不同，因此数据不能组合或相加在一起。即使所有试验的结果都是相同的，用于量化它们的具体结果衡量标准也可能不同。
Many questions regarding optimal therapeutics for specific patient problems remain to be answered. Clinical trials to address such questions may not be available. If they are, these trials may be underpowered due to the expense and logistical complexity of larger, multicenter trials. Pooling the results of small trials of the same therapy or intervention in a meta-analysis may also be fraught. Often, such trials assess subtly different outcomes, and therefore data cannot be combined or added together. Even if the outcomes are the same across trials, the specific outcome measures used to quantify them may not be.