The influence of malaria parasite genetic diversity and anaemia on mosquito feeding and fecundity
The influence of malaria parasite genetic diversity and anaemia on mosquito feeding and fecundity
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DOI：
10.1017/s0031182003003287
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发表时间：
2003-07-01
期刊：
影响因子：
2.4
通讯作者：
Read, AF
中科院分区：
文献类型：
--
作者：
Ferguson, HM;Rivero, A;Read, AF
无脊椎动物-寄生虫相互作用的研究经常报道感染会降低宿主的繁殖力。减少的程度可能取决于宿主和寄生虫的多种因素。通过室内实验，研究了疟原虫遗传和感染遗传多样性对携带疟原虫蚊子繁殖力的影响。疟疾媒介斯氏按蚊被两种不同基因型的啮齿动物疟疾寄生虫沙巴蒂疟原虫感染，或被两者的混合感染。混合基因型感染使蚊子繁殖力降低20%，显著高于2种单一基因型感染。混合基因型感染与小鼠的高配子体密度和贫血有关，这两者都与蚊子的血粉大小减少有关。血粉大小是蚊虫繁殖力最重要的预测因子；寄生虫的存在和数量没有直接影响。寄生虫密度影响蚊子捕食受感染小鼠的倾向，随着无性寄生虫和配子体密度的增加，蚊子捕食的比例更高。因此，蚊子可能会优先以对其繁殖力影响最大的宿主为食。
Studies of invertebrate-parasite interactions frequently report that infection reduces host fecundity. The extent of the reduction is likely to be determined by a wide range of host and parasite factors. We conducted a laboratory experiment to evaluate the role of parasite genetics and infection genetic diversity on the fecundity of mosquitoes carrying malaria parasites. The malaria vector Anopheles stephensi was infected with either of 2 different genotypes of the rodent malaria parasite Plasmodium chabaudi, or by a mixture of both. Mixed genotype infections reduced mosquito fecundity by 20%, significantly more than either of the 2 single genotype infections. Mixed genotype infections were associated with high gametocyte densities and anaemia in mice, both of which were correlated with reduced bloodmeal size in mosquitoes. Bloodmeal size was the most important predictor of mosquito fecundity; the presence and number of parasites had no direct effect. Parasite density influenced the propensity of mosquitoes to feed on infected mice, with a higher percentage of mosquitoes taking a meal as asexual parasite and gametocyte density increased. Thus mosquitoes may preferentially feed on hosts who will most impair their fecundity.