Clinical characteristics and presentation of lung cancer according to race and place of birth
Clinical characteristics and presentation of lung cancer according to race and place of birth
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DOI：
10.2217/fon.10.89
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发表时间：
2010-08-01
期刊：
影响因子：
3.3
通讯作者：
Taioli, Emanuela
中科院分区：
文献类型：
--
作者：
Said, Rabih;Terjanian, Terenig;Taioli, Emanuela
本研究根据出生地比较了白人和黑人肺癌患者的临床表现和特征，并将这些因素与预后相关。对三个三级医学中心2005-2007年间所有新诊断的肺癌患者进行了回顾；确定了767名患者，其中252名是黑人。从病历中检索年龄、性别、家族史、出生地、吸烟史、保险状况、临床分期、组织学、分化程度、症状、诊断、治疗情况和结局等资料。在白人个体中，28.2%的人被偶然诊断为肺癌，而在黑人个体中，这一比例为12.3%(p<；0.0001)。在调整其他变量后，黑人和白人的存活率相似(危险比：1.3；95%可信区间：0.8-2.0)。肺癌存活率的差异可能与获得护理的机会、环境因素和疾病的生物学有关。将出生地点纳入癌症结果研究可能有助于理解健康差距的根源。
This study compares the clinical presentation and characteristics of lung cancer among white and black patients according to place of birth, and correlates these factors to outcome. All newly diagnosed lung cancers from 2005 to 2007 in three tertiary medical centers were retrospectively reviewed; 767 patients were identified, 252 of whom were black. Age, sex, family history, place of birth, smoking history, insurance status, clinical stage, histology, grade of differentiation, symptoms, circumstance of diagnosis, treatment and outcome data were retrieved from medical charts. Lung cancer was diagnosed incidentally in 28.2% of white individuals versus 12.3% in black individuals (p < 0.0001). After adjustment for other variables, black and white individuals have similar survival rates (hazard ratio: 1.3; 95% CI: 0.8-2.0). The differences in lung cancer survival could be related to access to care, environmental factors and the biology of the disease. Including place of birth in cancer outcome studies could help understanding the origin of health disparity.