PATHOGENESIS OF NIDDM IN PIMA-INDIANS
PATHOGENESIS OF NIDDM IN PIMA-INDIANS
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DOI：
10.2337/diacare.14.7.685
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发表时间：
1991-07-01
期刊：
影响因子：
16.2
通讯作者：
BOGARDUS, C
中科院分区：
文献类型：
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作者：
BOGARDUS, C
据报道，亚利桑那州的皮马印第安人非胰岛素依赖型糖尿病 (NIDDM) 的患病率和发病率是世界上所有人群中最高的。 1982 年开始了一项横断面和纵向研究，以确定可预测 NIDDM 发展的代谢特征，并记录从正常到糖耐量受损再到糖尿病的转变中发生的代谢事件的顺序。 初步分析表明，胰岛素抵抗是导致皮马印第安人出现糖耐量受损的主要异常，并且糖尿病的发生伴随着随后的胰腺衰竭。
The Pima Indians of Arizona have the highest reported prevalence and incidence of non-insulin-dependent diabetes mellitus (NIDDM) of any population in the world. A cross-sectional and longitudinal study was begun in 1982 to determine the metabolic characteristic(s) that is (are) predictive of the development of NIDDM and to document the sequence of metabolic events that occur with the transition from normal to impaired glucose tolerance and then to diabetes. Preliminary analyses suggest that insulin resistance is a primary abnormality predisposing Pima Indians to develop impaired glucose tolerance, and that the development of diabetes occurs with subsequent pancreatic failure.