Allostatic load as a marker of cumulative biological risk: MacArthur studies of successful aging
Allostatic load as a marker of cumulative biological risk: MacArthur studies of successful aging
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DOI：
10.1073/pnas.081072698
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发表时间：
2001-04-10
影响因子：
11.1
通讯作者：
Singer, BH
中科院分区：
文献类型：
--
作者：
Seeman, TE;McEwen, BS;Singer, BH
稳态负荷（AL）已被提出作为一种新的概念，通过尝试适应生活的需求而对身体施加累积的生物负担。在对 1,189 名 70-79 岁男性和女性进行基线调查 7 年后，我们使用 AL 的多系统汇总测量方法评估了其预测四类健康结果的能力。较高的基线 AL 评分与 7 年死亡率的风险显着增加以及认知和身体功能下降相关，并且与心血管疾病事件的发生略有相关，与标准社会人口特征和基线健康状况无关。 AL 测量摘要基于 10 个生物功能参数，其中四个参数是从感知到的挑战到下游健康结果的级联中的主要调节因素。其中六个成分是次要介质，反映代谢综合征（X 综合征）的主要成分。与单独的 X 综合征或主要介质成分相比，AL 是死亡率和身体机能下降的更好预测因子。研究结果支持 AL 作为累积生物负荷衡量指标的概念。
Allostatic load (AL) has been proposed as a new conceptualization of cumulative biological burden exacted on the body through attempts to adapt to life's demands. Using a multisystem summary measure of AL, we evaluated its capacity to predict four categories of health outcomes, 7 years after a baseline survey of 1,189 men and women age 70-79. Higher baseline AL scores were associated with significantly increased risk for 7-year mortality as well as declines in cognitive and physical functioning and were marginally associated with incident cardiovascular disease events, independent of standard socio-demographic characteristics and baseline health status. The summary AL measure was based on 10 parameters of biological functioning, four of which are primary mediators in the cascade from perceived challenges to downstream health outcomes. Six of the components are secondary mediators reflecting primarily components of the metabolic syndrome (syndrome X). AL was a better predictor of mortality and decline in physical functioning than either the syndrome X or primary mediator components alone. The findings support the concept of AL as a measure of cumulative biological burden.