Intracolonic administration of zileuton, a selective 5-lipoxygenase inhibitor, accelerates healing in a rat model of chronic colitis
Intracolonic administration of zileuton, a selective 5-lipoxygenase inhibitor, accelerates healing in a rat model of chronic colitis
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DOI：
10.1136/gut.38.6.899
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发表时间：
1996-06-01
期刊：
影响因子：
24.5
通讯作者：
Gassull, MA
中科院分区：
文献类型：
--
作者：
Bertran, X;Mane, J;Gassull, MA
目的：在结肠炎大鼠模型上观察5-脂氧合酶抑制剂齐留通(Zileuton)对结肠损伤和二十烷类化合物局部释放的影响。方法：90只三硝基苯磺酸诱导的结肠炎大鼠随机分为安慰剂、5-氨基水杨酸(50 mg/kg)或齐留通(50 mg/kg)，连续4周。在整个研究过程中，通过结肠内透析监测局部二十烷基类药物的释放。每组10只大鼠分别于诱导结肠炎后1、2、4周取结肠进行大体及组织学检查。结果齐鲁通治疗4周后大体损伤评分明显低于其他两组(p=0.034)。此外，齐留通在第1周显著增加血栓素B-2(p=0.05)，在第2周和第4周显著增加前列腺素E(2)的释放(p
Background-5-Lipoxygenase products play a part in inflammatory response.Aims-The effect of intracolonic administration of zileuton (a 5-lipoxygenase inhibitor) on colonic damage and eicosanoid local release was assessed in a rat model of colitis.Methods-Ninety rats with trinitrobenzenesulphonic acid induced colitis were randomised to receive placebo, 5-amino-salicylic acid (50 mg/kg), or zileuton (50 mg/kg) intracolonically for four weeks. Local eicosanoid release was monitored by intracolonic dialysis throughout the study. The colon was removed for macroscopic and histological assessment at weeks 1, 2, and 4 after colitis induction in 10 rats of each group.Results-Zileuton significantly reduced macroscopic damage score after four weeks of treatment in comparison with the other two groups (p=0.034). In addition, zileuton administration significantly increased the intracolonic release of both thromboxane B-2 at week 1 (p=0.05) and prostaglandin E(2) at weeks 2 and 4 (p