Prevalence, Incidence, Clearance, and Associated Factors of Genital Human Papillomavirus Infection among Men: A Population-Based Cohort Study in Rural China
Prevalence, Incidence, Clearance, and Associated Factors of Genital Human Papillomavirus Infection among Men: A Population-Based Cohort Study in Rural China
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男性生殖器人乳头瘤病毒感染的患病率、发病率、清除率和相关因素：中国农村地区基于人群的队列研究。
DOI：
10.1158/1055-9965.epi-14-0365
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发表时间：
2014-12-01
影响因子：
3.8
通讯作者：
Ke, Yang
中科院分区：
文献类型：
--
作者：
Liu, Mengfei;He, Zhonghu;Ke, Yang
背景资料：人类乳头状瘤病毒（HPV）感染的自然历史在男性的人口基础上很少被研究，特别是在中国男性general.Methods：共1,286名男性年龄25至65岁，从中国农村在2009年至2010年期间入组，他们的生殖器HPV感染状况进行了评估，每半年进行多达7次访问，使用PCR和测序方法。在至少有一个有效HPV结果的男性中进行患病率分析（N = 1，279）和至少连续两次HPV结果的男性（N = 1，059）纳入发生率和清除率分析（中位随访时间为31.8个月;四分位距为15.4-37.9个月）。任何HPV类型、致癌性和非致癌性HPV的患病率和发病率分别为17.8%、6.4%、12.4%和14.6、4.9、10.8/1000人月。任何HPV类型、致癌性和非致癌性HPV感染的中位持续时间分别为11.5、6.8和11.5个月。终生性伴侣的数量与HPV流行和偶发感染的风险增加一致相关。25 ~ 50岁男性HPV感染的发生率和持续时间均高于老年男性（51-65岁）。结论和影响：本流行病学调查提供了中国男性生殖器HPV感染的基本信息，这些数据对于中国男性和女性人群HPV相关癌的主要策略的考虑至关重要。(C)2014年AACR。
Background: The natural history of human papillomavirus (HPV) infection in men on a population base has rarely been studied in general, particularly among Chinese men.Methods: A total of 1,286 men ages 25 to 65 years from rural China were enrolled during 2009-2010 and their genital HPV infection status was assessed biannually for up to seven visits using PCR and sequencing methods. Prevalence analysis was performed among men with at least one valid HPV result (N = 1,279) and men with at least two consecutive HPV results (N = 1,059) were included in incidence and clearance analyses (median follow-up time, 31.8 months; interquartile range, 15.4-37.9 months).Results: The prevalence and incidence of any HPV type, oncogenic, and nononcogenic HPV were 17.8%, 6.4%, 12.4%, and 14.6, 4.9, 10.8 per 1,000 person months, respectively. The median duration of infection with any HPV type, oncogenic, and nononcogenic HPV was 11.5, 6.8, and 11.5 months, respectively. The number of lifetime sexual partners was consistently associated with increased risk of prevalent and incident infection of HPV. Men ages 25 to 50 years had a higher incidence and longer duration of HPV infection than older men (51-65 years).Conclusions and Impact: This epidemiologic investigation provides basic information of genital HPV infection among the Chinese male population; these data are crucial for the consideration of primary strategies against HPV-related carcinoma in the Chinese male and female population. (C) 2014 AACR.