The roles of flotillin microdomains - endocytosis and beyond
The roles of flotillin microdomains - endocytosis and beyond
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DOI：
10.1242/jcs.092015
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发表时间：
2011-12-01
影响因子：
4
通讯作者：
Nichols, Benjamin J.
中科院分区：
文献类型：
--
作者：
Otto, Grant P.;Nichols, Benjamin J.
Flotillin是迄今为止研究的所有哺乳动物细胞类型的质膜中形成微结构域的膜蛋白。它们跨越了进化谱，与存在于细菌、真菌、植物和后生动物中的漂浮蛋白相关的蛋白质，这表明它们执行重要且可能保守的功能。Flotillins参与了无数的过程，包括内吞作用，信号转导和皮质细胞骨架的调节，但在这些不同情况下，Flotillins功能的分子机制仍然知之甚少。在这篇评论中，我们将介绍这些有趣的蛋白质，总结它们的拟议功能，并更详细地讨论一些最近的见解，flotilin微结构域的作用，内吞作用，已提供了几个独立的研究。最后，我们将重点讨论这些新实验提出的问题及其对未来研究的影响。
Flotillins are membrane proteins that form microdomains in the plasma membrane of all mammalian cell types studied to date. They span the evolutionary spectrum, with proteins related to flotillins present in bacteria, fungi, plants and metazoans, which suggests that they perform important, and probably conserved, functions. Flotillins have been implicated in myriad processes that include endocytosis, signal transduction and regulation of the cortical cytoskeleton, yet the molecular mechanisms that underlie flotillin function in these different cases are still poorly understood. In this Commentary, we will provide an introduction to these intriguing proteins, summarise their proposed functions and discuss in greater detail some recent insights into the role of flotillin microdomains in endocytosis that have been provided by several independent studies. Finally, we will focus on the questions that are raised by these new experiments and their implications for future studies.