Somatostatin (SRIF) prevents natural motoneuron cell death in embryonic chick spinal cord.
Somatostatin (SRIF) prevents natural motoneuron cell death in embryonic chick spinal cord.
复制标题
生长抑素 (SRIF) 可防止胚胎鸡脊髓中的自然运动神经元细胞死亡。
DOI：
10.1159/000112188
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发表时间：
1991
影响因子：
2.9
通讯作者：
Weill,CL
中科院分区：
文献类型：
--
作者：
Weill,CL
运动神经元的自然死亡是一个发育过程，影响脊髓外侧运动柱中约50%的细胞的丧失。本研究表明，在鸡胚脑运动神经元自然死亡期间，全身应用生长抑素(生长抑素)可使存活的运动神经元数目增加13-22%，提示生长抑素可能是正常发育过程中运动神经元存活的内源性因素。推测SRIF可能通过减少神经元内钙离子，在发育和成人神经退行性疾病过程中作为神经元死亡的内源性拮抗剂发挥作用。
Natural motoneuron cell death is a developmental process that effects the loss of about 50% of the cells in the lateral motor column of the spinal cord. The present study demonstrates that the systemic treatment of developing chick embryos with somatostatin (somatotropin release-inhibiting factor, SRIF) during the period of natural motoneuron cell death resulted in a 13–22% increase in the number of surviving motoneurons, suggesting that SRIF may be an endogenous contributor to motoneuron survival during normal development. It is hypothesized that SRIF may act, through its ability to reduce intraneuronal calcium, as an endogenous antagonist of neuronal death both during development and in the course of adult neurodegenerative diseases.