All‐in‐One Heptamethine Cyanine Amphiphiles for Dual Imaging‐Guided Chemo‐Photodynamic‐Photothermal Therapy of Breast Cancer
All‐in‐One Heptamethine Cyanine Amphiphiles for Dual Imaging‐Guided Chemo‐Photodynamic‐Photothermal Therapy of Breast Cancer
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DOI：
10.1002/adhm.202300941
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发表时间：
2023-06
影响因子：
10
通讯作者：
Y. Li;Jing Zhang;Lijun Zhu;Mou Jiang;Changsheng Ke;Hanxiong Long;Ruo-Chen Lin;Chaohui Ye;Xin Zhou;Zhong-Xing Jiang;Shizhen Chen
中科院分区：
文献类型：
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作者：
Y. Li;Jing Zhang;Lijun Zhu;Mou Jiang;Changsheng Ke;Hanxiong Long;Ruo-Chen Lin;Chaohui Ye;Xin Zhou;Zhong-Xing Jiang;Shizhen Chen
开发一种集成多模式成像、协同治疗和制剂实体的治疗系统是有效治疗癌症的一种有前途的策略。然而，多种功能实体的复杂性和安全性问题阻碍了它们的临床转化。在此，多功能的“all - in - one”七甲基菁两亲体（PEG‐Cy‐Fs）具有多种有利的功能，包括氟- 19磁共振成像（19F MRI）、近红外荧光成像（NIR FLI）、光动力治疗（PDT）、光热治疗（PTT）、聚乙二醇化（PEGylation）和高生物相容性，以方便构建治疗平台。两亲分子PEG‐Cy‐f是在几百毫克的范围内高效合成的，它与化疗药物他莫昔芬（TAM）自组装成单分散和稳定的纳米颗粒（SoFoTm/PEG‐Cy‐F18），具有“打开”的FLI，敏感的19F MRI，线粒体靶向能力，高PDT和PTT疗效，以及PEG‐酰化优化的药代动力学。SoFoTm/PEG‐Cy‐F18在MCF‐7肿瘤中选择性积累，并保持较长时间（10天），使19F MRI‐NIR FLI引导的化疗-光动力-光热疗法（chemo‐PDT‐PTT）在小鼠乳腺癌中具有高治疗指数。“all - in - one”七甲基氰氨酸两亲化合物可以方便和标准化地制备用于临床翻译的高性能治疗系统。
Developing a theranostic system that integrates multimodal imaging, synergistic therapeutic, and formulation entities is a promising strategy for efficient cancer treatment. However, the complexity and safety concerns of multiple functional entities hinder their clinical translation. Herein, versatile “all‐in‐one” heptamethine cyanine amphiphiles (PEG‐Cy‐Fs) with multiple favorable capabilities, including fluorine‐19 magnetic resonance imaging (19F MRI), near‐infrared fluorescence imaging (NIR FLI), photodynamic therapy (PDT), photothermal therapy (PTT), polyethylene glycolation (PEGylation) and high biocompatibility, are developed for the convenient construction of theranostic platforms. Amphiphiles PEG‐Cy‐Fs are synthesized on a multi‐hundred‐milligram scale with high efficacy, which self‐assembled with a chemotherapy drug tamoxifen (TAM) into monodisperse and stable nanoparticles (SoFoTm/PEG‐Cy‐F18) with “turned on” FLI, sensitive 19F MRI, mitochondria‐targeting ability, high PDT and PTT efficacy, and PEGylation‐optimized pharmacokinetics. The selective accumulation of SoFoTm/PEG‐Cy‐F18 in xenograft MCF‐7 tumor with a long retention time (>10 days) enabled 19F MRI‐NIR FLI‐guided chemo–photodynamic–photothermal therapy (chemo‐PDT‐PTT) of breast cancer with high therapeutical index in mice. The “all‐in‐one” heptamethine cyanine amphiphile may facilitate the convenient and standardized preparation of high‐performance theranostics systems for clinical translation.