Developmental changes in resting and functional cerebral blood flow and their relationship to the BOLD response.
Developmental changes in resting and functional cerebral blood flow and their relationship to the BOLD response.
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静息和功能性脑血流的发育变化及其与 BOLD 反应的关系。
DOI：
10.1002/hbm.22394
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发表时间：
2014
影响因子：
4.8
通讯作者：
Liu,ThomasT
中科院分区：
文献类型：
--
作者：
Moses,Pamela;DiNino,Mishaela;Hernandez,Leanna;Liu,ThomasT
我们对健康发育大脑中的脑血流量（CBF）的了解有限，这是由于历史上可用于CBF测量的方法的侵入性。使用放射性示踪剂对儿童进行的基于临床的研究集中在静息状态CBF。然而，刺激期间血流的潜在年龄相关变化可能会影响用于研究认知神经发育的血氧水平依赖性（BOLD）反应。本研究使用无创动脉自旋标记磁共振成像，比较了8岁、12岁和成人正常发育儿童之间的静息状态和刺激驱动CBF。此外，我们同时获得功能CBF和BOLD图像，以检查它们在感觉刺激过程中的关系。分析显示，在休息期间与年龄相关的CBF差异;最年轻的组显示出比12奥尔兹或成年人更大的CBF。在听觉皮层的刺激过程中，年幼的儿童也表现出比成人更大的CBF绝对增加。然而，两组间CBF反应高于基线的幅度相当。同样，BOLD反应的幅度在不同年龄段都是稳定的。8岁奥尔兹的CBF升高，无论是在休息时还是对刺激的反应中，BOLD反应都没有升高，这表明在BOLD效应中也起作用的其他生理因素，例如在此期间也升高的代谢过程，可能会抵消这些儿童的CBF增加。因此，CBF测量揭示了儿童中BOLD效应背后的血液动力学的成熟差异，尽管儿童和成人之间的BOLD反应相似。©2013 Wiley Periodicals，Inc.
Our understanding of cerebral blood flow (CBF) in the healthy developing brain has been limited due to the invasiveness of methods historically available for CBF measurement. Clinically based studies using radioactive tracers with children have focused on resting state CBF. Yet potential age‐related changes in flow during stimulation may affect the blood oxygenation level dependent (BOLD) response used to investigate cognitive neurodevelopment. This study used noninvasive arterial spin labeling magnetic resonance imaging to compare resting state and stimulus‐driven CBF between typically developing children 8 years of age, 12 years of age, and adults. Further, we acquired functional CBF and BOLD images simultaneously to examine their relationship during sensory stimulation. Analyses revealed age‐related CBF differences during rest; the youngest group showed greater CBF than 12‐year‐olds or adults. During stimulation of the auditory cortex, younger children also showed a greater absolute increase in CBF than adults. However, the magnitude of CBF response above baseline was comparable between groups. Similarly, the amplitude of the BOLD response was stable across age. The combination of the 8 year olds' elevated CBF, both at rest and in response to stimulation, without elevation in the BOLD response suggests that additional physiological factors that also play a role in the BOLD effect, such as metabolic processes that are also elevated in this period, may offset the increased CBF in these children. Thus, CBF measurements reveal maturational differences in the hemodynamics underlying the BOLD effect in children despite the resemblance of the BOLD response between children and adults.Hum Brain Mapp 35:3188–3198, 2014. ©2013 Wiley Periodicals, Inc.