Breast feeding and the development of juvenile rheumatoid arthritis.
Breast feeding and the development of juvenile rheumatoid arthritis.
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发表时间：
1995
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通讯作者：
T. Mason;Rabinovich Ce;Fredrickson Dd;K. Amoroso;Ann M. Reed;Stein Ld;Kredich Dw
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作者：
T. Mason;Rabinovich Ce;Fredrickson Dd;K. Amoroso;Ann M. Reed;Stein Ld;Kredich Dw
目的 确定患有幼年类风湿性关节炎 (JRA) 的儿童是否比对照组儿童接受母乳喂养的可能性更低。方法 采用病例对照研究，对 54 名 JRA 儿童的母亲和 79 名玩伴进行母乳喂养调查，获得数据。将母乳喂养的持续时间制成表格，并确定优势比 (OR) 和 95% 置信区间 (CI)。结果 与玩伴相比，JRA 儿童母乳喂养的 OR 为 0.40（0.20-0.81，95% CI）。对于少关节 JRA (N = 28)，OR 为 0.31 (0.10-0.93)；在多关节 JRA (N = 24) 中，OR 为 0.60 (0.21-1.70)。在患有 JRA 的儿童中，母乳喂养时间增加的 OR 较低。结论 患有 JRA 的儿童，尤其是少关节 JRA 的儿童，母乳喂养的可能性低于对照组，这表明母乳喂养可能对 JRA 的发展具有保护作用。
OBJECTIVE To determine if children with juvenile rheumatoid arthritis (JRA) are less likely to have been breast fed than controls. METHODS Case-control study of data obtained from a survey of mothers 54 children with JRA and 79 playmates regarding breast feeding. Duration of breast feeding was tabulated and odds ratios (OR) with 95% confidence intervals (CI) were determined. RESULTS OR for breast feeding in children with JRA was 0.40 (0.20-0.81, 95% CI) compared to playmates. For pauciarticular JRA (N = 28) OR was 0.31 (0.10-0.93); in polyarticular JRA (N = 24) OR was 0.60 (0.21-1.70). Lower OR for increased durations of breast feeding were noted in children with JRA. CONCLUSION Children who have had JRA, especially pauciarticular JRA, are less likely to have been breast fed than controls, suggesting that breast feeding may have a protective effect on the development of JRA.